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Small stress proteins and human diseases /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hauppauge, N.Y. :
Nova Science,
2010.
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| Colección: | Protein science and engineering.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- SMALL STRESS PROTEINS AND HUMAN DISEASES; PROTEIN SCIENCE AND ENGINEERING; Contents; Preface; Abbreviations; Introduction to Small Heat Shock Proteins; Abstract; 1. Evolutionary Aspects; 2. Structure of small Stress Proteins; 3. Expression of sHSPs; 4. Post-Translational Modifications of sHSPs; 5. Interactions with Unfolding Proteins; 6. Interactions with Partner Proteins; 6.1. Interactions amongst sHSPs; 6.2. Interactions with the Cytoskeleton; 6.3. Interaction with Apoptotic Proteins; 6.4. Interaction with the Degradation Machinery; 7. Involvement of sHSPs in Diseases; Acknowledgments.
- 4. Mammalian HspB Neuroprotective Function May Be, at Least in Part, Independent on their "Chaperone-Like" Activity4.1. HspB1; 4.1.1. HspB1 and Huntington Disease; 4.1.2. HspB1 and Amyotrophic Lateral Sclerosis; 4.1-3. HspB1 and Tauopathies; 4.2. HspB5; 4.2.1. HspB5 and Congenital Cataract; 4.2.2. HspB5 and Parkinson; 4.2.3. HspB5 and Alexander Disease; 4.2.4. HspB5 and Multiple Sclerosis; 4.3. HspB8; 4.3.1. HspB8 and Alzheimer Disease; 4.3.2. HspB8 and Polyglutamine Disorders; Conclusion; References.
- Functional Symbiosis between the Intermediate Filament Cytoskeleton and Small Heat Shock ProteinsAbstract; 1. The Evolutionary Context
- Bacterial Cytoskeleton, Stress and the Origins of the SIF Complex; 2. The Cytoskeleton
- The Key to Cell Mechanics and Resisting Stress; 3. Intermediate Filaments are Bona Fide Stress Proteins and Symbiotic Partners in the SIF Complex; 4. sHSP Interactions with IFs; 5. Lessons From IF Based Diseases; 6. Interaction of sHSPs with Other Client Proteins of the Cytoskeleton; 6.1. Actin Cytoskeleton; 6.2. Myosin Interactions
- Preserving ATPase Activity.
- 6.3. The Third Filament System of Muscle
- Titin6.4. Cadherin
- Kidney Specific (Ksp)
- Interactions; 6.5. Microtubules; 7. Filament Binding Sites; Conclusion; Acknowledgments; References; The Two Lens Structure Proteins, A-Crystallin (HspB4) and B-Crystallin (HspB5), Control Apoptosis through Regulation of Multiple Signaling Transduction Pathways; Abstract; Introduction; 1. The Biology of the Ocular Lens; 2. Apoptosis and Cataractogenesis in the Ocular Lens; 3. Discovery of the Anti-apoptotic Role of -Crystallins; 4. ( -Crystallins Prevents Developmental and Stress-Induced Apoptosis.