Tabla de Contenidos:
  • RECENT TRENDS IN BIOTECHNOLOGY VOLUME 2 ; RECENT TRENDS IN BIOTECHNOLOGY VOLUME 2 ; Contents ; Preface ; Aging: The Current Perspectives ; Abstract ; Introduction ; Theories of Aging ; Evolutionary Theory ; Free Radical Theory ; Somatic Mutation Theory ; Error Theory ; Gene Regulation Theory ; Gene Expression and Regulation during Aging; Hallmarks of Aging; Brain Structure and Function in Aging; Effects of Aging on Memory ; Age Related Brain Associated Diseases ; Alzheimer's Disease ; Parkinson's Disease ; Can Aging Be Prevented?
  • Interventional Stem Cell Therapy to Prevent Aging and Age Related Neurodegenerative Diseases Treatment of AD ; Treatment of PD ; Future Scope; Conclusion ; References ; RNA Interference: Small Being Mighty ; Abstract ; Introduction; Types of Small RNAs in Mammalian Systems ; 1. MicroRNA (miRNA) ; 2. Small Interfering RNA (siRNA) ; 3. piwi RNA (piRNA) ; 4. Endo-siRNAs ; Silencing Machinery ; 1. Dicer ; 2. Argonaute ; 3. TRBP, Loquacious and Other RNA Binding Proteins ; 4. Exportin 5 ; Growing Interests in RNA Interference ; RNAi as a Tool to Understand Gene Function in vitro and in vivo.
  • Micrornas in DevelopmentMicrorna and Disease ; Viral Infections; Bacterial and Parasitic Infections ; Genetic Diseases ; Microrna in Cancer ; Roadblocks to RNAi as Drugs; 1. Saturating Endogenous Pathways ; 2. Stimulation of Innate Immune Response ; 3. Off-Target Effects ; 4. Efficacy and Stability ; 5. In Vivo Delivery Systems; Conclusion ; Useful Links to Small RNA Databases; References ; Chromatin and Transcription: Regulation of Plant Genes ; Abstract; Introduction ; 1. Nucleosomes as Barrier in Transcription ; 2. Histone Modifications to Remove the Nucleosomes.
  • 2.1. ATP-Dependent Chromatin Remodeling2.1.1. Chromatin Remodeling Machineries ; 2.1.1.1. SWI/SNF Family ; 2.1.1.2. ISWI Family ; 2.1.1.3. CHD Family ; 2.1.2. Mechanisms of Nucleosome Remodeling; 2.1.3. Chromatin Remodeling Machineries in Plants ; 2.2 Covalent Histone Modifications; 2.2.1. Histone Acetylation and Histone Acetyltransferases ; 2.2.1.1. Histone Acetyltransferase Complex: SAGA Complex; 2.2.2. Histone Deacetylation ; 2.2.2.1. Histone Deacetyltransferase ; 2.2.2.2. Histone Deacetylases in Plants ; 2.2.3. Histone Methylation ; 2.2.3.1. Histone lysine methylation.
  • 2.2.3.2. Histone Lysine Demethylation 2.2.4. Arginine Methylation ; 2.2.5. Histone Phosphorylation ; Histone Modifications for Lasting Effect on Gene Repression/Expression ; Gene Repression: Flowering Locus C: ; Gene Activation: Phaseolin Promoter ; Effects of Histone Modifications on Nucleosomal Positioning in Tobacco PR-1a Promoter ; Conclusion ; References ; Vaccines: Perspectives and Trends ; Abstract ; Introduction ; Features of an Ideal Vaccine ; Innate and Adaptive Immune Responses ; Immunization ; Passive Immunization ; Limitations of Passive Immunization ; Active Immunization.