Mitochondria : structure, functions, and dysfunctions /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Svensson, Oliver L.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Science, ©2010.
Colección:Cell biology research progress.
Temas:
Mitochondria.
Mitochondria > physiology
Mitochondria > metabolism
Mitochondria > pathology
Mitochondria
Mitochondries.
SCIENCE > Life Sciences > Cell Biology.
Mitochondriën.
Pathologische fysiologie.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • MITOCHONDRIA: STRUCTURE, FUNCTIONS AND DYSFUNCTIONS
  • MITOCHONDRIA: STRUCTURE, FUNCTIONS AND DYSFUNCTIONS
  • Contents
  • Preface
  • Mitochondria: The Portrayal of an Executioner
  • Abstract
  • Introduction
  • II. Apoptotic Pathways
  • II. A. Extrinsic Pathways
  • II. B. Perforin-Granzyme B Pathways
  • II. C. Intrinsic Pathways
  • II. D. Execution Pathway
  • III. Mitochondria and Gateways to Mitochondrial Death
  • III. A. Mitochondria and Cell
  • III. B. Regulation of Mitochondrial Membrane Permeabilization
  • III. B.1. Non-protein mediators
  • Calcium
  • Lipid and lipid metabolitesSmall molecules
  • III. B.2. Protein mediators: Bcl-2 family-intrinsic regulators of cellular life and death
  • III. B.2.1. Properties of Bcl-2 family members
  • III. B.2.2. Upstream of mitochondria: Activation of BCL-2 family members
  • III. B.2.3. Post-translational modifications determine active/inactive conformations
  • III. B.2.3.a. Dimerization
  • III. B.2.3.b. Translocation
  • III. B.2.3.c. Phosphorylation
  • III. B.2.3.d. Cleavage
  • III. B.2.3.e. Transcription
  • III. B.2.4. Pro-apoptotic BCL-2 members as sentinels for cellular damage
  • III. C. Characteristics of Apoptotic Membrane PermeabilizationIII. D. Models of Mitochondrial Membrane Permeabilization
  • III. D.1. Permeabilization of the inner membrane along with the rupture of the Outer Membrane
  • III. D.2. The adenine nucleotide transporter
  • III. D.3. BCL-XL and ADP/ATP Exchange
  • III. D.4. Selective permeabilization of the Outer Mitochondrial Membrane
  • III. D.5. Outer Membrane permeabilization by VDAC
  • III. E. Mitochondrial Membrane Permeabilization and Released Factors
  • III. E.1. Cytochrome c
  • III. E.2. Daiblo/Smac
  • III. E.3. HtrA2/Omi
  • III. E.4. Procaspase-2 and 9III. E.5. Hsp 10, Hsp60
  • III. E.6. AIF
  • III. E.7. Release of Endonuclease G
  • III. E.8. Adenylate Kinase 2
  • III. F. Outcome of Mitochondrial Membrane Permeabilization
  • III. F.1. Apoptosome
  • Active versus inactive apoptosomes
  • The role of cytochrome c and dATP in apoptosome assembly and caspase-9 processing
  • III. F.2. Breakdown of oxidative phosphorylation
  • IV. PTPC Structure and Mitochondrial Permeability Transition- A Final Word
  • V. Effects of Mitochondria Membrane Permeabilization
  • VI. Afferent Signals Form Other Organelles Inducing MMPVI. A. Nuclear DNA Damage
  • VI. A.1. Signals from the “guardian of genomeâ€? to mitochondria
  • VI. B. Endoplasmic Reticulum
  • VI. C. Lysosomes
  • VI. D. Cytosol
  • VI. D.1. The ubiquitin/proteasome complex
  • VI. D.2. The phosphatidylinositol-3-kinase pathway
  • VI. D.3. Apoptosis signal-regulating kinase/mitogen-activated protein kinase
  • VI. E. Cytoskeleton
  • VII. Apoptosis, Mitochondria and Human Disease
  • VII. A. Ischemia/Reperfusion
  • VII. B. Aging and Mitochondrial Damage

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