G protein-coupled receptors : structure, signaling, and physiology /

"This text provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel sig...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Siehler, Sandra, Milligan, Graeme
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge : Cambridge University Press, ©2011.
Temas:
G proteins.
Cell receptors.
Cellular signal transduction.
GTP-Binding Proteins
Receptors, Cell Surface
Signal Transduction
Protéines G.
Récepteurs cellulaires.
Transduction du signal cellulaire.
SCIENCE > Life Sciences > Biochemistry.
Cell receptors
Cellular signal transduction
G proteins
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Part I. Advances in GPCR Protein Research: 1. The evolution of the repertoire and structure of G protein-coupled receptors / Torsten Schöneberg, Kristin Schröck, Claudia Stäubert and Andreas Russ
  • 2. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles / Adam J. Kuszak, Xiao Jie Yao, Sören G.F. Rasmussen, Brian K. Kobilka and Roger K. Sunahara
  • Part II. Oligomerization of GPCRs: 3. GPCR-G protein fusions : use in functional dimerization analysis / Graeme Milligan
  • 4. Time-resolved FRET approaches to study GPCR complexes / Jean Phillipe Pin, Damien Maurel, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and Erin Trinquet
  • 5. Signaling of dopamine receptor homo- and hetero-oligomers / Ahmed Hasbi, Brian F. O'Dowd and Susan R. George
  • 6. Functional consequences of chemokine receptor dimerization / Mario Mellado, Carlos Martínez-A., and José Miguel Rodgríguez-Frade
  • Part III. GPCR Signaling Features: 7. G protein functions identified using genetic mouse models / Stefan Offermanns
  • 8. Kinetics of GPCR, G protein and effector activation / Peter Hein
  • 9. RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling / José Vázquez-Prado and J. Silvio Gutkind
  • 10. Adenylyl cyclase isoform-specific signaling of GPCRs / Karin F.K. Ejendal, Julie A. Przybyla, and Val J. Watts
  • 11. G protein-independent and [beta] arrestin-dependent GPCR signaling / Zhongzhen Nie and Yehia Daaka
  • 12. Assays to read GPCR modulation and signaling / Ralf Heilker and Michael Wolff
  • Part IV. Ligand Pharmacology of GPCRs: 13. Quantifying allosteric ligand-receptor interactions / Ivan Toma Vranesic and Daniel Hoyer
  • 14. 7TM receptor functional selectivity / Terry Kenakin
  • Part V. Physiological Functions and Drug Targeting of GPCRs: 15. [Beta]-Adrenoreceptors in cardiovascular and respiratory diseases / Michele Ciccarelli, J. Kurt Chuprun and Walter J. Koch
  • 16. Role of metabotropic glutamate receptors in CNS disorders / Richard M. O'Connor and John F. Cryan
  • 17. S1P receptor agonists, a novel generation of immunosuppressants / Rósa Lopez Almagro, Gema Tarrasón, and Nuria Godessart
  • 18. Wnt/Frizzled receptor signaling in osteoporosis / Georges Rawadi.

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