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Drug discovery and development for Alzheimer's disease 2000 /
This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's t...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Springer Pub Co.,
©2002.
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| Colección: | ISOA Annual Investigators Meeting.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 1. The Challenges of Drug Discovery and Drug Development for Cognitive Aging and Alzheimer's Disease / Howard Fillit and Alan O'Connell
- pt. I. Early Detection
- 2. Genetic Correlates of Successful Cognitive Aging / Thomas Perls
- 3. Genetic and Environmental Risk Factors for Alzheimer's Disease in Arabs Residing in Israel / Robert P. Friedland, Amos Korczyn and Lindsay Farrer
- 4. Telephonic Screening of Mental Status: A Feasibility Study in a Managed Care Clinic / David Knopman, Thomas Vonsternberg and Jim Haefemeyer
- 5. Use of Brain MRI Volumetric Analysis in a Mild Cognitive Impairment Trial to Delay the Diagnosis of Alzheimer's Disease / Michael Grundman, Drahomira Sencakova and Clifford R. Jack, Jr. / [and others]
- 6. Hippocampal Volume Assessment in Mild Cognitive Impairment / Michael S. Mega, Paul M. Thompson and Arthur W. Toga / [and others]
- 7. Brain Imaging Surrogate Markers for Detection and Prevention of Cognitive Aging and Alzheimer's Disease / Gary W. Small
- 8. Novel [beta]-Amyloid Probes / Mei-Ping Kung, Zhi-Ping Zhuang and Catherine Hou / [and others]
- 9. Early Clinical and Biological Manifestations of Alzheimer's Disease: Implications for Screening and Treatment / Richard C. Mohs, Deborah Marin and Vahram Haroutunian
- pt. II. Drug Discovery
- 10. Identification of Brain-Expressed ABC Transporters That May Mediate Detachment of [beta]-Amyloid From Biological Membranes / Peter B. Reiner and Stephane Le Bihan
- 11. Targeting an RNA Structure in the Amyloid Precursor Protein Gene as a New Therapeutic Strategy for Alzheimer's Disease / Jack T. Rogers
- 12. Novel Tricyclic Pyrone Compounds Prevent Intracellular APP C99-Induced Cell Death / Lee-Way Jin, Duy H. Hua and Feng-Shiun Shie / [and others]
- 13. Novel Glycosaminoglycans as Antiamyloid Agents / Robert Kisilevsky and Walter A. Szarek
- 14. Strategies for Inhibiting Alzheimer's [gamma]-Secretase / Michael S. Wolfe
- 15. Phosphorylations of Tau and APP as Targets for Drug Discovery / John DeBernardis, Dan Kerkman and Cintia Vianna / [and others]
- 16. Estrogen and ApoE: Drug Discovery Implications / Jonathan D. Smith and Justine A. Levin
- 17. Structure-Based Functional Design of Agonists and Antagonists for AMPA-Subtype Glutamate Receptors / Ming-Ming Zhou, Harel Weinstein and Diomedes E. Logothetis / [and others]
- 18. Alzheimer's Therapeutics: Neurotrophin Small Molecule Mimetics / Stephen M. Massa, You-Mei Xie and Frank M. Longo
- pt. III. Drug Development
- Preclinical
- 19. Antioxidants in the Treatment of Alzheimer's Disease: Breakthrough Potential of Indole-3-Propionic Acid / Daniel G. Chain, Douglas Galasko and Eyal Neria / [and others]
- 20. AF150(S) and AF267B: M1 Muscarinic Agonists for Treatment and as Disease-Modifying Agents in Alzheimer's and Related Diseases / A. Fisher, Z. Pittel and R. Brandeis / [and others]
- 21. ABS-205: Effects on Cognition in Mature and Aged Rats / Ciaran M. Regan
- 22. Calpain Inhibitors: A Treatment of Alzheimer's Disease / Ottavio Arancio
- 23. Femtomolar-Acting Neuroprotective Peptides: Application for Inhibition of Alzheimer's Disease / Illana Gozes, Sharon Furman and Ruth A. Steingart / [and others]
- pt. IV. Drug Development
- Clinical
- 24. A Phase I Clinical Study of Ex Vivo Nerve Growth Factor Gene Therapy for Alzheimer's Disease / Mark H. Tuszynski
- 25. Lowering Homocysteine Levels in Patients With Alzheimer's Disease / Paul Aisen, Mary Sano and Ramon Diaz-Arrastia / [and others]
- 26. Therapeutic Potential of Positive AMPA Receptor Modulators in Mild Cognitive Impairment and Alzheimer's Disease / Steven A. Johnson, Gary Lynch and Gary A. Rogers / [and others]
- 27. The Alzheimer's Disease Atorvastatin Treatment Trial: Scientific Basis and Position on the Use of HMG-CoA Reductase Inhibitors (Statins) That Do or Do Not Cross the Blood-Brain Barrier / D. Larry Sparks, Donald J. Connor and Patrick J. Browne / [and others]
- 28. A Double-Blind, Randomized Investigation of the Effects of Testosterone or Placebo in Male Patients With Mild-to-Moderate Alzheimer's Disease / Bruce Miller
- 29. Estrogen and Cognitive Functioning in Men With Mild Cognitive Impairment / Barbara B. Sherwin and Howard Chertkow.