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DNA microarray technology and data analysis in cancer research /
DNA microarray technology has become a useful technique in gene expression analysis for the development of new diagnostic tools and for the identification of disease genes and therapeutic targets for human cancers. Appropriate control for DNA microarray experiment and reliable analysis of the array...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Singapore ; Hackensack, NJ :
World Scientific,
©2008.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Li, Shaoguang. | |
| 245 | 1 | 0 | |a DNA microarray technology and data analysis in cancer research / |c Shaoguang Li, Dongguang Li. |
| 260 | |a Singapore ; |a Hackensack, NJ : |b World Scientific, |c ©2008. | ||
| 300 | |a 1 online resource (xi, 118 pages) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
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| 504 | |a Includes bibliographical references (pages 105-115) and index. | ||
| 505 | 0 | |a ch. 1. DNA microarray technology. 1.1. Experimental procedure. 1.2. Experimental design. 1.3. Quality control. 1.4. Interpretation of DNA microarray data. 1.5. Advantages and disadvantages -- ch. 2. Applications of DNA microarray technology in cancer research. 2.1. Solid tumors. 2.2. Blood cancers. 2.3. Our DNA microarray study using mouse -- ch. 3. Current analytical methods of DNA microarray data. 3.1. Experimental design. 3.2. Method. 3.3. Quality control diagnostics. 3.4. Statistical analysis. 3.5. Coefficient of variation analysis -- ch. 4. A novel method for DNA microarray data analysis : SDL global optimization method. 4.1. Research subjects. 4.2. Experimental design. 4.3. Fold change analysis -- 4.4. More information on SDL global optimization -- ch. 5. Applications of the SDL global optimization method in DNA microarray data analysis. 5.1. Leukemia cell line study. 5.2. Analyses of publicly available human microarray data. 5.3. Overall methodology. 5.4. Experimental results. 5.5. Discussion. 5.6. Conclusion -- ch. 6. General discussion and future directions. | |
| 520 | |a DNA microarray technology has become a useful technique in gene expression analysis for the development of new diagnostic tools and for the identification of disease genes and therapeutic targets for human cancers. Appropriate control for DNA microarray experiment and reliable analysis of the array data are key to performing the assay and utilizing the data correctly. The most difficult challenge has been the lack of a powerful method to analyze the data for all genes (more than 30,000 genes) simultaneously and to use the microarray data in a decision-making process. In this book, the authors describe DNA microarray technology and data analysis by pointing out current advantages and disadvantages of the technique and available analytical methods. Crucially, new ideas and analytical methods based on the authors' own experience in DNA microarray study and analysis are introduced. It is believed that this new way of interpreting and analyzing microarray data will bring us closer to success in decision-making using the information obtained through the DNA microarray technology. | ||
| 588 | 0 | |a Print version record. | |
| 546 | |a English. | ||
| 590 | |a eBooks on EBSCOhost |b EBSCO eBook Subscription Academic Collection - Worldwide | ||
| 650 | 0 | |a Cancer cells |x Growth |x Regulation. | |
| 650 | 0 | |a DNA microarrays. | |
| 650 | 0 | |a Diseases. | |
| 650 | 0 | |a Methodology. | |
| 650 | 0 | |a Research. | |
| 650 | 0 | |a Gene expression. | |
| 650 | 0 | |a Science. | |
| 650 | 0 | |a Nucleic acid hybridization. | |
| 650 | 0 | |a Decision making |x Mathematical models. | |
| 650 | 0 | |a Genetics |x Technique. | |
| 650 | 0 | |a Physical sciences. | |
| 650 | 2 | |a Genetic Phenomena | |
| 650 | 2 | |a Disease | |
| 650 | 2 | |a Methods | |
| 650 | 2 | |a Sequence Analysis | |
| 650 | 2 | |a Oligonucleotide Array Sequence Analysis |x methods | |
| 650 | 2 | |a Oligonucleotide Array Sequence Analysis | |
| 650 | 2 | |a Neoplasms | |
| 650 | 2 | |a Data Interpretation, Statistical | |
| 650 | 2 | |a Research | |
| 650 | 2 | |a Gene Expression | |
| 650 | 2 | |a Science | |
| 650 | 2 | |a Investigative Techniques | |
| 650 | 2 | |a Molecular Probe Techniques | |
| 650 | 2 | |a Microarray Analysis | |
| 650 | 2 | |a Nucleic Acid Hybridization | |
| 650 | 2 | |a Decision Support Techniques | |
| 650 | 2 | |a Analytical, Diagnostic and Therapeutic Techniques and Equipment | |
| 650 | 2 | |a Genetic Techniques | |
| 650 | 2 | |a Microchip Analytical Procedures | |
| 650 | 2 | |a Natural Science Disciplines | |
| 650 | 2 | |a Chemistry Techniques, Analytical | |
| 650 | 2 | |a Phenomena and Processes | |
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| 650 | 6 | |a Prise de décision |x Modèles mathématiques. | |
| 650 | 6 | |a Génétique |x Technique. | |
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| 650 | 7 | |a Methodology |2 fast | |
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| 650 | 7 | |a Diseases |2 fast | |
| 650 | 7 | |a Decision making |x Mathematical models |2 fast | |
| 650 | 7 | |a Cancer cells |x Growth |x Regulation |2 fast | |
| 650 | 7 | |a DNA microarrays |2 fast | |
| 700 | 1 | |a Li, Dongguang. | |
| 776 | 0 | 8 | |i Print version: |a Li, Shaoguang. |t DNA microarray technology and data analysis in cancer research. |d Singapore ; Hackensack, NJ : World Scientific, ©2008 |w (DLC) 2009277979 |
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