Toxicity of alternatives to chlorofluorocarbons : HFC-134a and HCFC-123 /

As part of the effort to phase out the use of stratospheric ozone-depleting substances, such as chlorofluorocarbons (CFCs) and Halon gases, the U.S. Navy is planning to substitute hydrofluorocarbon (HFC)-134a for the refrigerant CFC-12, and the Air Force is planning to substitute hydrochlorofluoroca...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Washington, D.C. : National Academy Press, 1996.
Temas:
Air > Pollution.
Chlorofluorocarbons > Environmental aspects.
Hydrocarbons, Fluorinated > toxicity
Chlorofluorocarbons > adverse effects
Bromochlorofluorocarbons > adverse effects
Flame Retardants > toxicity
Toxicity Tests
Chlorofluorocarbones > Aspect de l'environnement.
SCIENCE > Chemistry > Organic.
United States
Computer network resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Toxicity of Alternatives to Chlorofluorocarbons: HFC-134a and HCFC-123
  • Copyright
  • Preface
  • Contents
  • Executive Summary
  • ASSESSMENT OF MODEL FOR CARDIAC SENSITIZATION
  • EXPOSURE GUIDANCE LEVELS FOR HFC-134A
  • EXPOSURE GUIDANCE LEVEL FOR HCFC-123
  • 1 Introduction
  • STATEMENT OF TASK
  • DEFINITIONS
  • Emergency Exposure Guidance Level
  • Continuous Exposure Guidance Level
  • STRUCTURE OF THE REPORT
  • 2 Evaluation of the Dog Cardiac Sensitization Test
  • INTRODUCTION
  • MECHANISM OF ACTION FOR CHEMICALLY INDUCED ARRHYTHMIAS
  • PROTOCOL FOR A CARDIAC SENSITIZATION SCREENING STUDY.
  • CARDIAC SENSITIZATION EXPERIMENTS INVOLVING SELECTED HALOCARBONS
  • CONCLUSION
  • REFERENCES
  • 3 Exposure Guidance Levels for Hydrofluorocarbon-134a
  • INTRODUCTION
  • BACKGROUND INFORMATION
  • Physical and Chemical Properties
  • Occurrence and Use
  • TOXICOKINETICS
  • TOXICITY INFORMATION
  • Acute Toxicity
  • Cardiac Sensitization
  • Subacute Toxicity
  • Subchronic Toxicity
  • Developmental Toxicity
  • Reproductive Toxicity
  • Genotoxicity
  • Carcinogenicity
  • SUMMARY
  • RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS
  • REFERENCES
  • 4 Exposure Guidance Levels for Hydrochlorofluorocarbon-123.
  • INTRODUCTION
  • RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS
  • REFERENCES
  • Appendix A
  • SUPPORTING DOCUMENTATION FOR THE EXPOSURE GUIDANCE LEVELS FOR HYDROCHLOROFLUOROCARBON-123
  • BACKGROUND INFORMATION
  • Physical and Chemical Properties
  • Occurrence and Use
  • TOXICOKINETICS
  • TOXICITY INFORMATION
  • Effects in Humans
  • Effects in Animals
  • Single-Exposure Studies
  • Repeat-Exposure Studies
  • EXPOSURE ASSESSMENT
  • RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVEL
  • REFERENCES
  • ATTACHMENT 1 MATERIAL SAFETY DATA SHEET
  • ATTACHMENT 2 HALOTHANE
  • BACKGROUND INFORMATION.
  • Physical and Chemical Properties
  • Occurrence and Use
  • ACUTE TOXICITY INFORMATION
  • Acute Toxicity and CNS Depression
  • Cardiac Sensitization
  • Effects in Humans
  • Malignant Hyperthermia
  • Hepatotoxicity
  • DISCUSSION
  • HCFC-123 AND Halothane Comparison
  • Acute Toxicity and CNS Depression
  • Cardiac Sensitization
  • Malignant Hyperthermia
  • Hepatotoxicity
  • REFERENCES
  • ATTACHMENT 3 SUMMARY OF TOXICITY STUDIES OF HCFC-123
  • I. ANIMAL STUDIES: SINGLE EXPOSURE
  • II. ANIMAL STUDIES: REPEAT EXPOSURE
  • III. REFERENCES.
  • ATTACHMENT 4 SUMMARY OF ACUTE PHARMACOKINETIC STUDY OF HCFC-123 IN DOGS BY INHALATION
  • OBJECTIVE
  • MATERIALS AND METHODS
  • Exposure System
  • Blood and Tissue Sampling
  • Analysis of Blood and Tissue Samples
  • RESULTS
  • DISCUSSION.

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