Induction and analysis of antigen-specific T cell responses in melanoma patients and animal models /

In the last century, it has become clear that in patients suffering certain types of cancer, spontaneous activation of the immune sytem may lead to curation. The concept of immunotherapy is based on that notion. The intention is to stimulate T cells direc.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Bins, Adriaan Dirk
Formato: Tesis Electrónico eBook
Idioma:Inglés
Publicado: [Leiden] : Leiden University Press, ©2007.
Edición:2nd ed.
Temas:
Melanoma > Immunological aspects > Research.
Immunocompetent cells > Research.
T cells > Research.
Cancer vaccines > Research.
Mélanome > Immunologie > Recherche.
Cellules immunocompétentes > Recherche.
Vaccins anticancéreux > Recherche.
MEDICAL > Oncology.
HEALTH & FITNESS > Diseases > Cancer.
Academic Dissertation
Academic theses.
Thèses et écrits académiques.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Introduction; Ch. 1: On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients.; Ch. 2:Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GM-CSF in advanced-stage HLA-A*0201- positive melanoma patients.; Ch. 3: A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression; Ch. 4:Superior immunogenicity of DNA tattooing as compared to intramuscular DNA vaccination in non-human primates.; Ch. 5: In vivo antigen stability affects vaccine efficacy.

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