Cancer drug design and discovery /

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The ultimate source of information on the design of new anticancer agents, emphasising small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Neidle, Stephen (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Academic Press, ©2008.
Edición:1st ed.
Temas:
Antineoplastic agents > Development.
Antineoplastic agents > Design.
Cancer > Chemotherapy.
Antimitotic agents.
Antineoplastic agents.
Drugs > Design.
Antineoplastic Agents
Antimitotic Agents
Drug Design
Neoplasms > drug therapy
Cancer > Chimiothérapie.
Anticancéreux.
Médicaments > Conception.
MEDICAL > Oncology.
HEALTH & FITNESS > Diseases > Cancer.
Drugs > Design
Antineoplastic agents
Antimitotic agents
Antineoplastic agents > Design
Antineoplastic agents > Development
Cancer > Chemotherapy
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Modern cancer drug discovery : integrating targets, technologies and treatments / Paul Workman and Ian Collins
  • Preclinical pharmacology and in vivo models / Lloyd Kelland
  • Clinical trial designs for more rapid proof-of-principle and approval / Mitesh J. Borad and Daniel D. Van Hoff
  • Structural biology and anticancer drug design / Dominic Tisi [and others]
  • Natural product chemistry and anticancer drug discovery / Donna M. Huryn and Peter Wipf
  • Pharmacokinetics and ADME optimization in drug discovery / Chad L. Stoner, Matthew D. Troutman and Caroline E. Laverty
  • Temozolomide : from cytotoxic to molecularly-targeted agent / Malcolm F.G. Stevens
  • Camptothecins for drug design, cancer cell death and gene targeting / Jérôme Kluza [and others]
  • Targeting thymidylate synthase by antifolate drugs for the treatment of cancer / Ann L. Jackman, Martin Forster and Matthew Ng
  • Targeting inactive kinases : structure as a foundation for cancer drug discovery / David J. Hosfield and Clifford D. Mol
  • Cell cycle inhibitors in cancer : current status and future directions / Peter M. Fischer
  • Inhibition of DNA repair as a therapeutic target / Nicola J. Curtin and Thomas Helleday
  • HSP90 inhibitors : targeting the cancer chaperone for combinatorial blockade of oncogenic pathways / Swee Y. Sharp, Keith Jones and Paul Workman
  • Heat shock protein-90 directed therapeutics and target validation / Edward A. Sausville
  • Inhibitors of tumor angiogenesis / Adrian L. Harris and Daniele G. Generali
  • The biology and oncology of RAF-ERK signaling / Victoria Emuss and Richard Marais
  • Cancer drug resistance / V. Karavasilis [and others]
  • Failure modes in anticancer drug discovery and development / Homer L. Pearce, Kerry L. Blanchard and Christopher A. Slapak.

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