Use of high performance computing in meteorology : proceedings of the Twelfth ECMWF Workshop, Reading, UK, 30 October - 3 November 2006 /

Adult or postnatal stem cells offer life-long cell replacement in tissues and organs, and are thus unavoidable targets of long-term and transient regenerative/epigenetic gene therapy for both inherited and acquired diseases; and effective anticancer therapy. In particular, autologous stem cells have...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores Corporativos: ECMWF Workshop on the Use of High Performance Computing in Meteorology Reading, Great Britain, European Centre for Medium Range Weather Forecasts
Otros Autores: Mozdzynski, George
Formato: Electrónico Congresos, conferencias eBook
Idioma:Inglés
Publicado: Singapore ; Hackensack, NJ : World Scientific, ©2007.
Temas:
Meteorology > Mathematical models > Data processing > Congresses.
Atmospheric physics > Mathematical models > Data processing > Congresses.
Parallel processing (Electronic computers) > Congresses.
Supercomputers > Congresses.
Physique de l'atmosphère > Modèles mathématiques > Informatique > Congrès.
Parallélisme (Informatique) > Congrès.
Superordinateurs > Congrès.
SCIENCE > Earth Sciences > Meteorology & Climatology.
Atmospheric physics > Mathematical models > Data processing.
Meteorology > Mathematical models > Data processing.
Parallel processing (Electronic computers)
Supercomputers.
Conference papers and proceedings.
Acceso en línea:Texto completo
Descripción
Sumario:Adult or postnatal stem cells offer life-long cell replacement in tissues and organs, and are thus unavoidable targets of long-term and transient regenerative/epigenetic gene therapy for both inherited and acquired diseases; and effective anticancer therapy. In particular, autologous stem cells have been instrumental to the success of gene therapy, enabling breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders). This timely book highlights the pioneering translation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells to contribute to all three germ players. Pathologies are discussed in terms of stem cell repopulation dynamics, with appropriate niches (long-term engraftment) and tissues (cell turnover). Focus is also placed on the increasing number of identified tissue-specific cancer stem cells as the ultimate targets for recurrence-free cancer recovery, and on the development of armed stem cells as tumor-homing vectors for targeted anticancer stem cell gene therapy.
Descripción Física:1 online resource (viii, 273 pages) : illustrations (some color), maps
Bibliografía:Includes bibliographical references.
ISBN:9789812775894
9812775897
1281928933
9781281928931
9786611928933
6611928936

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