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Molecular neurology /

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Waxman, Stephen G.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Burlington, MA : Elsevier Academic Press, ©2007.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • PREFACE Stephen G. Waxman
  • Section I. Principles of Molecular Neurology.
  • Genetics as a Tool in Neurology.
  • Neurology and Genomic Medicine.
  • Mitochondrial Function and Dysfunction in the Nervous System.
  • Neuronal Channels and Receptors.
  • Protein Misfolding, Chaperone Networks, and the Heat Shock Response
  • in the Nervous System.
  • Metabolic Biopsy of the Brain.
  • Gene therapy approaches in neurology.
  • Programmed Cell Death and its Role in Neurological Disease.
  • Section II. Disorders of Development.
  • Developmental Neurology: A Molecular Perspective.
  • Metabolic Diseases of the Nervous System.
  • Genetic Disorders of Neuromuscular Development.
  • Section III. Stroke and Trauma.
  • Molecular Mechanisms of Ischemic Brain Disease.
  • Hemorrhagic Brain Disease.
  • The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury.
  • Section IV. Degenerative Diseases.
  • Parkinsons Disease: Molecular Insights.
  • The molecular basis of Alzheimers disease.
  • Polyglutamine Disorders including Huntingtons Disease.
  • Friedreichs Ataxia and Related RNA Loss-Of-Function Disorders.
  • DYT1, a Primary Torsion Dystonia.
  • Motor Neuron Disease: Amyotrophic Lateral Sclerosis.
  • Genetic Disorders of the Autonomic Nervous System.
  • Multiple sclerosis as a neurodegenerative disease.
  • Section V. Disorders of Excitation and Transmission.
  • Acquired Epilepsy: Cellular and Molecular Mechanisms.
  • Genetic Epilepsies.
  • Tourettes Syndrome.
  • Section VI. Disorders of Sleep and Circadian Rhythms.
  • Disorders of Sleep and Circadian Rhythms.
  • Section VII. Pain
  • Cronic pain as a molecular disorder.
  • Migraine as a cerebral ionopathy with impaired central sensory processing.
  • Section VIII. Peripheral Nerve Disease.
  • Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies.
  • Section IX. Neuro-Immunology.
  • Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis.
  • Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal.
  • Paraneoplastic Neurologic Syndromes.
  • Mitochondrial Disorders.
  • Section X. Infectious Disorders.
  • Molecular Neurology of HIV-1 Infection and AIDs.
  • Genetics as a tool in neurology
  • Neurology and genomic medicine
  • Mitochondrial function and dysfunction in the nervous system
  • Neuronal channels and receptors
  • Protein misfolding, chaperone networks, and the heat shock response in the nervous system
  • Metabolic biopsy of the brain
  • Gene therapy approaches in neurology
  • Programmed cell death and its role in neurological disease
  • Developmental neurology: a molecular perspective
  • Metabolic diseases of the nervous sytsem
  • Genetic disorders of neuromuscular development
  • Molecular mechanisms of ischemic brain disease
  • Hemorrhagic brain disease
  • The Dawn of molecular and cellular therapies for traumatic spinal cord injury
  • Parkinson disease: molecular insights
  • The Molecular basis of Alzheimer's disease
  • Polyglutamine disorders including Huntington's disease
  • Friedreich's ataxia and related DNA loss-of-function disorders
  • DYT1, an inherited dystonia.
  • Motor neuron disease: amyotrophic lateral sclerosis
  • Genetic disorders of the autonomic nervous system
  • Multiple sclerosis as a neurodegenerative disease
  • Acquired epilepsy: cellular and molecular mechanisms
  • Genetic epilepsies
  • Tourette's syndrome
  • Disorders of sleep and circadian rhythms
  • Chronic pain as a molecular disorder
  • Migraine as a cerebral ionopathy with impaired central sensory processing
  • Myelin protein zero and CMT 1 B: a tale of two phenotypes
  • Demyelinating diseases: immunological mechanisms in the pathogenesis of multiple sclerosis
  • Autoimmune and genetic disorders of the neuromuscular junction and motor nerve terminal
  • Paraneoplastic neurologic syndromes
  • Mitochondrial disorders
  • Molecular neurology of HIV-1 infection and AIDS.