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Target validation in drug discovery /

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug develo...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Metcalf, Brian W., Dillon, Susan, 1952-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Boston : Academic Press, ©2007.
Temas:
Acceso en línea:Texto completo
Descripción
Sumario:This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book
Descripción Física:1 online resource (xii, 279 pages) : illustrations
Bibliografía:Includes bibliographical references and index.
ISBN:9780123693938
0123693934
9780080465975
0080465978