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Forensic DNA typing : biology, technology, and genetics of STR markers /
This enormously successful book gains ten new chapters providing valuable insight on this fascinating new technology!
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier Academic Press,
©2005.
|
| Edición: | 2nd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Overview and history of DNA typing
- DNA biology review
- Sample collection, DNA extraction and DNA quantitation
- The polymerase chain reaction (DNA amplification)
- Commonly used short tandem repeat markers and commercial kits
- Biology of STRs : stutter products, non-template addition, microvariants, null alleles, and mutation rates
- Forensic issues : degraded DNA, PCR inhibition, contamination, mixed samples and low copy number
- Single nucleotide polymorphisms and other bi-allelic markers
- Y chromosome DNA testing
- Mitochondrial DNA analysis
- Non-human DNA testing and microbial forensics
- DNA separation methods : slab-gel and capillary electrophoresis
- DNA detection methods : fluorescent dyes and silver-staining
- Instrumentation for STR typing : ABI 310, ABI 3100, FMBIO systems
- STR genotyping issues
- Laboratory validation
- New technologies, automation, and expert systems
- Combined DNA index system (CODIS) and the use of DNA databases
- Basic genetic principles, statistics, and probability
- STR population database analyses
- Profile frequency estimates, likelihood ratios, and source attribution
- Approaches to statistical analysis of mixtures and degraded DNA
- Kinship and parentage testing
- Mass disaster DNA victim identification.