Self-perpetuating structural states in biology, disease, and genetics /

Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phe...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores Corporativos: Arthur M. Sackler Colloquia of the National Academy of Sciences Washington, D.C., National Academy of Sciences (U.S.) (sponsoring body.)
Otros Autores: Lindquist, Susan (Editor ), Henikoff, Steve (Editor )
Formato: Electrónico Congresos, conferencias eBook
Idioma:Inglés
Publicado: Washington, DC : National Academy of Sciences, [2002]
Colección:Sackler Colloquium series
Temas:
Cellular control mechanisms > Congresses.
Biology > Congresses.
DNA > Congresses.
Prions > Congresses.
Chromatin > Congresses.
Proteins > Conformation > Congresses.
Proteins > Conformation.
Chromatin > genetics
Epigenesis, Genetic
Histones > genetics
Protein Conformation
Régulation cellulaire > Congrès.
Biologie > Congrès.
ADN > Congrès.
Prions (Virologie) > Congrès.
Chromatine > Congrès.
Protéines > Conformation > Congrès.
Protéines > Conformation.
SCIENCE > Essays.
SCIENCE > Nanoscience.
SCIENCE > Reference.
Biology
Cellular control mechanisms
Chromatin
DNA
Prions
Proteins > Conformation
Andre fag (naturvidenskab og teknik) > Andre fag
Congress
proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Acceso en línea:Texto completo
Descripción
Sumario:Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance. Protein-only inheritance involves the transmission of phenotypes by self-perpetuating changes in protein conformation. Proteins that constitute chromatin can also transmit heritable information, for example, via posttranslational modifications of histones. Both the transmission of phenotypes via the formation of protein conformations and the inheritance of chromatin states involve self-perpetuating assemblies of proteins, and there is evidence for some common structural features and conceptual frameworks between them. To foster interactions between researchers in these two fields, the National Academy of Sciences convened an Arthur M. Sackler Colloquium entitled "Self-Perpetuating Structural States in Biology, Disease, and Genetics" in Washington, DC, on March 22-24, 2002. Participants described new phenomenology and provided insights into fundamental mechanisms of protein and chromatin inheritance. Perhaps most surprising to attendees was emerging evidence that these unconventional modes of inheritance may be common.
Notas:Title from title screen.
Descripción Física:1 online resource : illustrations
Bibliografía:Includes bibliographical references.
ISBN:0309084458
9780309084451
030957045X
9780309570459

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