Tabla de Contenidos:
  • DIAGNOSIS AND CONTROL OF JOHNE'S DISEASE
  • Copyright
  • Acknowledgments
  • Preface
  • Contents
  • Executive Summary
  • THE TASK
  • CONCLUSIONS
  • DISEASE CONTROL
  • EDUCATION AND TRAINING
  • RESEARCH
  • Epidemiology of Map Infection and JD
  • Diagnostics and Immunology
  • Map Genome Studies
  • Vaccine Development
  • Human and Animal Health Issues
  • 1 Introduction
  • THE COMMITTEE'S TASK
  • 2 Johne's Disease in Domesticated and Wild Animals
  • SPECTRUM OF DISEASE IN DOMESTICATED ANIMALS
  • Cattle
  • Stage I: Silent Infection
  • Stage II: Subclinical DiseaseStage III: Clinical Disease
  • Stage IV: Advanced Clinical Disease
  • Sheep and Goats
  • SPECTRUM OF DISEASE IN OTHER ANIMALS
  • PATHOLOGY
  • Cattle
  • Lesions of Subclinical Infection
  • Lesions of Clinical Infection
  • Sheep
  • Goats
  • Exotic Ruminants
  • Non-ruminant Species
  • Primates
  • Rabbits
  • Other Species
  • EPIDEMIOLOGY
  • Global Prevalence in Domesticated Animals
  • Prevalence in Wildlife and Zoo Animals
  • MODES OF TRANSMISSION
  • Fecal-Oral Transmission
  • Congenital Transmission
  • Lactation TransmissionCross-Species Transmission
  • Sanitation
  • Environmental Factors
  • Water
  • Soil Characteristics
  • Pasteurization
  • PATHOGENESIS IN CATTLE
  • Age-Related Susceptibility
  • Genetic Susceptibility
  • Immune Response
  • Sequencing of the Map Genome
  • 3 Diagnostics
  • TESTING OF DOMESTICATED ANIMALS
  • Bacteriologic Culture
  • Decontamination of Specimens
  • Concentration of Map from Specimens
  • Conventional Culture for Map
  • Automated Culture
  • Radiometric Systems
  • Nonradiometric Systems
  • Pooled Fecal Culture
  • Sensitivity of Fecal CultureImmunologic Tests
  • Detecting the Cell-Mediated Response
  • Skin Testing
  • Lymphocyte Blastogenesis and Transformation
  • Gamma Interferon
  • Serologic Tests to Detect the Humoral Response
  • Complement Fixation Test
  • Agar Gel Immunodiffusion
  • Enzyme-Linked Immunosorbent Assay
  • Test Result Measures
  • Fixed-Decision Thresholds or Cutoffs
  • Information Cost and Degree of Result Categorization
  • Likelihood Ratios and ROC Curves
  • MOLECULAR METHODS
  • IS900
  • Molecular Strain Typing
  • EPIDEMIOLOGIC TOOLS
  • Test Protocol StandardizationLaboratory Proficiency Evaluation
  • 4 Control Principles and Programs
  • CONTROL PRINCIPLES
  • Environmental Factors in Infection Control Practices
  • Producer Awareness and Adoption of Biosecurity Practices and Control Measures
  • Control Programs with a Single-Agent Focus
  • Vaccination
  • Herd-Level Control
  • Dairy Herds
  • Beef Herds
  • Sheep Flocks
  • Goat Herds
  • Zoos and Game Farms
  • CURRENT CONTROL PROGRAMS
  • National Programs
  • NJWG and Control Plans
  • NJWG 1998 Program
  • USDA 2002 Program