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245 0 0 |a Copper in drinking water /  |c Committee on Copper in Drinking Water, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council. 
260 |a Washington, D.C. :  |b National Academy Press,  |c ©2000. 
300 |a 1 online resource (147 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a data file 
500 |a "This project was supported by Cooperative Agreement No. CR827277-01 between the National Academy of Sciences and the U.S. Environmental Protection Agency"--Title page verso 
504 |a Includes bibliographical references. 
588 0 |a Print version record. 
505 0 |a Copper in Drinking Water -- Copyright -- Preface -- Contents -- Executive Summary -- THE CHARGE TO THE COMMITTEE -- THE COMMITTEE'S APPROACH TO ITS CHARGE -- THE COMMITTEE'S EVALUATION -- Health Effects of Excess Copper -- Recommendations -- Physiological Role of Copper -- Recommendations -- Sensitive Populations -- Recommendations -- Risk Characterization -- Recommendations -- 1 Introduction -- CHEMICAL AND PHYSICAL PROPERTIES -- SOURCES OF COPPER IN DRINKING WATER -- COMMITTEE'S APPROACH TO ITS CHARGE -- STRUCTURE OF THE REPORT -- REFERENCES 
505 8 |a 2 Physiological Role of CopperESSENTIALITY -- BIOCHEMISTRY AND PHYSIOLOGY -- FACTORS AFFECTING BIOAVAILABILITY -- Effect of Age -- Dietary and Other Interactions -- CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 3 Health Effects of Copper Deficiencies -- TERATOGENESIS OF COPPER DEFICIENCY -- Causes of Copper Deficiency -- Copper in Prenatal Development -- Drug-Induced Copper Deficiency -- Disease-Induced Copper Deficiency -- Copper-Diet Interactions -- Gene-Induced Copper Deficiency -- Human Copper Deficiency and Teratogenesis 
505 8 |a Primary Dietary Copper DeficiencyHEALTH EFFECTS OF COPPER DEFICIENCIES IN ADULTS -- CONCLUSIONS -- REFERENCES -- 4 Disorders of Copper Homeostasis -- MENKES DISEASE -- OCCIPITAL HORN SYNDROME -- WILSON DISEASE -- GENETIC CHARACTERISTICS OF WILSON AND MENKES DISEASES -- HETEROZYGOTES FOR WILSON DISEASE -- ACERULOPLASMINEMIA -- TYROLEAN INFANTILE CIRRHOSIS -- INDIAN CHILDHOOD CIRRHOSIS -- IDIOPATHIC COPPER TOXICOSIS -- OTHER GENETIC DISORDERS -- DISEASE-INDUCED CHANGES IN COPPER HOMEOSTASIS -- CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES 
505 8 |a 5 Health Effects of Excess CopperACUTE TOXICITY -- Case Reports and Population-Based Studies -- CHRONIC TOXICITY -- Reproductive and Developmental Toxicity -- Genotoxicity, Mutagenicity, and Carcinogenicity of Copper -- Sensitive Populations -- Carriers of Genetic Defects in Copper Homeostasis -- Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD) -- ANIMAL STUDIES -- Toxicity in Animals -- Reproductive and Developmental Toxicity -- Neurotoxicity -- Carcinogenicity -- Mechanisms and Animal Models for Copper Toxicity -- Mechanism of Acute Copper Toxicity 
505 8 |a Mechanism of Chronic Copper ToxicityCONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 6 Risk Characterization -- COPPER DEFICIENCY -- COPPER TOXICITY FROM SINGLE OR SHORT-TERM EXPOSURE -- COPPER TOXICITY FROM CHRONIC EXPOSURE -- Sensitive Populations -- Carriers of the Wilson-Disease Gene and Other Genetically Sensitive Groups -- Infants -- Chronic Liver Disease -- Glucose-6-Phosphate Dehydrogenase Deficiency -- Implications for the MCLG -- CHRONIC COPPER EXPOSURE THROUGH TAP WATER -- DIETARY CONTRIBUTION AND TOTAL COPPER INTAKE -- Formula-Fed Infants 
546 |a English. 
590 |a eBooks on EBSCOhost  |b EBSCO eBook Subscription Academic Collection - Worldwide 
650 0 |a Copper  |x Toxicology. 
650 0 |a Drinking water  |x Copper content. 
650 0 |a Copper  |x Metabolism  |x Disorders. 
650 1 2 |a Copper  |x adverse effects 
650 2 2 |a Copper  |x physiology 
650 2 2 |a Environmental Exposure  |x standards 
650 2 2 |a Water Supply  |x standards 
650 6 |a Cuivre  |x Toxicologie. 
650 6 |a Eau potable  |x Teneur en cuivre. 
650 6 |a Cuivre  |x Troubles du métabolisme. 
650 7 |a TECHNOLOGY & ENGINEERING  |x Environmental  |x Water Supply.  |2 bisacsh 
650 7 |a Copper  |x Metabolism  |x Disorders  |2 fast 
650 7 |a Copper  |x Toxicology  |2 fast 
650 7 |a Drinking water  |x Copper content  |2 fast 
650 1 7 |a Drinkwater.  |2 gtt 
650 1 7 |a Koper.  |2 gtt 
650 1 7 |a Toxicologie.  |2 gtt 
710 2 |a National Research Council (U.S.) 
776 0 8 |i Print version:  |t Copper in drinking water.  |d Washington, D.C. : National Academy Press, ©2000  |z 0309069394  |w (DLC) 00102668 
856 4 0 |u https://ebsco.uam.elogim.com/login.aspx?direct=true&scope=site&db=nlebk&AN=33538  |z Texto completo 
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938 |a Internet Archive  |b INAR  |n copperindrinking0000unse 
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938 |a YBP Library Services  |b YANK  |n 2316810 
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