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050 4 |a RA1224.2  |b .B56 1989eb 
060 4 |a WQ 205  |b B61547 1989 
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049 |a UAMI 
245 0 0 |a Biologic markers in reproductive toxicology /  |c Subcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council. 
260 |a Washington, D.C. :  |b National Academy Press,  |c 1989. 
300 |a 1 online resource (xxi, 395 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references (pages 319-372) and index. 
505 0 |a Executive summary -- Report of the Oversight Committee. I. Biologic markers in male reproductive and gametic genetic toxicology. Introduction -- Clinical evaluation of male infertility -- Biologic markers of testicular function -- Biologic markers of epididymal structure and function -- Biologic markers of accessory sex organ structure and function -- Biologic markers of human male reproductive health and physiologic damage -- Assessing transmitted mutations in mice -- Markers for measuring germinal genetic toxicity and heritable mutations in people -- Conclusions and recommendations. II. Biologic markers in female reproductive toxicology. Introduction -- Biologic markers of genetic damage in females -- Biologic markers of reproductive development and aging -- Biologic markers of nonconceptive menstrual cycles -- Developing assays of biologic markers for epidemiologic studies: experience with a marker of pregnancy and early loss -- Conclusions and recommendations. III. Biologic markers of toxicity during pregnancy. Introduction -- Molecular biology: developing DNA markers of genotoxic effects -- Reproductive immunology: biologic markers of compromised pregnancies -- Cell biology: identifying biologic markers expressed during early pregnancy -- Physiologic assessment of fetal compromise -- Conclusions and Recommendations. IV. Biologic Markers in Neurodevelopmental Toxicology. Introduction -- Developmental neurobiology of the central nervous system -- Morphologic, neurochemical, and behavioral responses to toxic agents -- Methodologic issues of extrapolation from animal studies to human toxicant exposure -- Lead as a paradigm for the study of neurodevelopmental toxicology -- Conclusions and recommendations -- Appendix: Assessing the validity of biologic markers: alpha-fetoprotein -- References -- Biographies -- Index. 
506 |3 Use copy  |f Restrictions unspecified  |2 star  |5 MiAaHDL 
533 |a Electronic reproduction.  |b [Place of publication not identified] :  |c HathiTrust Digital Library,  |d 2010.  |5 MiAaHDL 
538 |a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.  |u http://purl.oclc.org/DLF/benchrepro0212  |5 MiAaHDL 
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588 0 |a Print version record. 
590 |a eBooks on EBSCOhost  |b EBSCO eBook Subscription Academic Collection - Worldwide 
650 0 |a Reproductive toxicology. 
650 0 |a Biochemical markers. 
650 2 |a Biomarkers 
650 2 |a Environmental Pollutants  |x adverse effects 
650 2 |a Reproduction 
650 6 |a Toxicologie de la reproduction. 
650 6 |a Marqueurs biologiques. 
650 7 |a MEDICAL  |x Reproductive Medicine & Technology.  |2 bisacsh 
650 7 |a Biochemical markers  |2 fast 
650 7 |a Reproductive toxicology  |2 fast 
650 7 |a Fortpflanzung  |2 gnd 
650 7 |a Toxikologie  |2 gnd 
650 7 |a Biomarker  |2 gnd 
650 7 |a Aufsatzsammlung  |2 gnd 
710 2 |a National Research Council (U.S.).  |b Subcommittee on Reproductive and Neurodevelopmental Toxicology. 
776 0 8 |i Print version:  |t Biologic markers in reproductive toxicology.  |d Washington, D.C. : National Academy Press, 1989  |z 0309039797  |w (DLC) 89003071  |w (OCoLC)19268308 
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