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Tabla de Contenidos:
  • Background and historical perspectives
  • IOM report
  • Cross-cutting recommendations
  • Uses of antiprogestins: the reproductive cycle
  • Contraception
  • Post-coital contraception
  • Menses induction
  • Uses of antiprogestins: the reproductive cycle
  • Pregnancy termination during the first trimester
  • Pregnancy termination during the second trimester
  • Cervical ripening
  • Labor induction in late pregnancy
  • Other therapeutic uses of antiprogestins
  • Endometriosis
  • Uterine leiomyomas (fibroids)
  • Breast cancer
  • Meningiomas
  • Antiglucocorticoid effects of antiprogestins
  • Glucocorticoid function
  • Therapeutic use of mifepristone (RU 486) as an antiglucocorticoid
  • Adverse antiglucocorticoid effects of antiprogestins
  • Animals as models for studying antiprogestins
  • Agenda for the IOM workshop "Antiprogestins: Assessing the Science"
  • Background papers and presentations (in order of presentation at IOM workshop)
  • 1993: RU 486: a decade on today and tomorrow / Etienne-Emile Baulieu.
  • (cont) Overview and background: mechanism of action of antiprogestins / Nancy L. Weigel
  • Use of antiprogestins in the reproductive cycle / Lynnette Kaye Nieman
  • Potential contraceptive effects of antigestogens / David T. Baird
  • Use of antiprogestins before 63 days of amenorrhea / Marc Bygdeman
  • Uses of antiprogestins after 63 days of amenorrhea / Ancre Ulmann and Louise Silvestre
  • Comments on session II
  • David Grimes
  • Use of antiprogestins in the management of endometriosis and leiomyoma / Samuel S.C. Yen
  • Antiprogestins and the treatment of breast cancer / Kathryn B. Horwitz
  • Uses of RU 486 as an antiglucocorticoid / Lynnette Kaye Nieman
  • Primate models for the study of antiprogestins in reproductive medicine / Gary D. Hodgen
  • Antiprogestogens: perspectives from a global research program / P.F.A. Van Look and H. von Hertzen
  • Observers at the workshop on antiprogestins.