Basic Pharmacokinetics and Pharmacodynamics An Integrated Textbook and Computer Simulations.

Detalles Bibliográficos
Autor principal: Rosenbaum, Sara E.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Newark : John Wiley & Sons, Incorporated, 2016.
Colección:New York Academy of Sciences Ser.
Temas:
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Title page
  • Copyright
  • Dedication
  • Preface
  • Contributors
  • Chapter 1 Introduction to Pharmacokinetics and Pharmacodynamics
  • 1.1 Introduction: Drugs and Doses
  • 1.2 Introduction to Pharmacodynamics
  • 1.3 Introduction to Pharmacokinetics
  • 1.4 Dose-Response Relationships
  • 1.5 Therapeutic Range
  • 1.6 Summary
  • Reference
  • Chapter 2 Passage of Drugs Through Membranes
  • 2.1 Introduction
  • 2.2 Structure and Properties of Membranes
  • 2.3 Passive Diffusion
  • 2.4 Carrier-Mediated Processes: Transport Proteins
  • References
  • Chapter 3 Drug Administration and Drug Absorption
  • 3.1 Introduction: Local and Systemic Drug Administration
  • 3.2 Routes of Drug Administration
  • 3.3 Overview of Oral Absorption
  • 3.4 Extent of Drug Absorption
  • 3.5 Determinants of the Fraction of the Dose Absorbed (F)
  • 3.6 Factors Controlling the Rate of Drug Absorption
  • 3.7 Biopharmaceutics Classification System
  • 3.8 Food Effects
  • Problems
  • References
  • Chapter 4 Drug Distribution
  • 4.1 Introduction
  • 4.2 Extent of Drug Distribution
  • 4.3 Rate of Drug Distribution
  • 4.4 Distribution of Drugs to the Central Nervous System
  • Problems
  • Note
  • References
  • Chapter 5 Drug Elimination and Clearance
  • 5.1 Introduction
  • 5.2 Clearance
  • 5.3 Renal Clearance
  • 5.4 Hepatic Elimination and Clearance
  • Problems
  • References
  • Chapter 6 Compartmental Models in Pharmacokinetics
  • 6.1 Introduction
  • 6.2 Expressions for Component Parts of the Dose-Plasma Concentration Relationship
  • 6.3 Putting Everything Together: Compartments and Models
  • 6.4 Examples of Complete Compartment Models
  • 6.5 Use of Compartmental Models to Study Metabolite Pharmacokinetics
  • 6.6 Selecting and Applying Models
  • Problems
  • Suggested Readings
  • Chapter 7 Pharmacokinetics of an Intravenous Bolus Injection in a One-Compartment Model
  • 7.1 Introduction
  • 7.2 One-Compartment Model
  • 7.3 Pharmacokinetic Equations
  • 7.4 Simulation Exercise
  • 7.5 Application of the Model
  • 7.6 Determination of Pharmacokinetic Parameters Experimentally
  • 7.7 Pharmacokinetic Analysis in Clinical Practice
  • Problems
  • Suggested Reading
  • Chapter 8 Pharmacokinetics of an Intravenous Bolus Injection In A Two-Compartment Model
  • 8.1 Introduction
  • 8.2 Tissue and Compartmental Distribution of a Drug
  • 8.3 Basic Equation
  • 8.4 Relationship Between Macro and Micro Rate Constants
  • 8.5 Primary Pharmacokinetic Parameters
  • 8.6 Simulation Exercise
  • 8.7 Determination of the Pharmacokinetic Parameters of the Two-Compartment Model
  • 8.8 Clinical Application of the Two-Compartment Model
  • Problems
  • Suggested Readings
  • Chapter 9 Pharmacokinetics of Extravascular Drug Administration
  • 9.1 Introduction
  • 9.2 First-Order Absorption in a One-Compartment Model
  • 9.3 Modified Release and Gastric Retention Formulations
  • 9.4 Bioavailability
  • 9.5 IN VITRO-IN VIVO Correlation
  • 9.6 Simulation Exercise
  • Problems

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