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230209s2016 xx o ||| 0 eng d |
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|a EBLCP
|b eng
|c EBLCP
|d OCLCQ
|d EBLCP
|d OCLCQ
|d OCLCO
|d OCLCQ
|d OCLCL
|d OCLCQ
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| 020 |
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|a 9781119143185
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| 020 |
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|a 1119143187
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| 035 |
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|a (OCoLC)1347029027
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|a 615/.7
|q OCoLC
|2 23/eng/20230216
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| 049 |
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|a UAMI
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| 100 |
1 |
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|a Rosenbaum, Sara E.
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| 245 |
1 |
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|a Basic Pharmacokinetics and Pharmacodynamics
|h [electronic resource] :
|b An Integrated Textbook and Computer Simulations.
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| 260 |
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|a Newark :
|b John Wiley & Sons, Incorporated,
|c 2016.
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| 300 |
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|a 1 online resource (763 p.).
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| 490 |
1 |
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|a New York Academy of Sciences Ser.
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| 500 |
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|a Description based upon print version of record.
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| 505 |
0 |
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|a Intro -- Title page -- Copyright -- Dedication -- Preface -- Contributors -- Chapter 1 Introduction to Pharmacokinetics and Pharmacodynamics -- 1.1 Introduction: Drugs and Doses -- 1.2 Introduction to Pharmacodynamics -- 1.3 Introduction to Pharmacokinetics -- 1.4 Dose-Response Relationships -- 1.5 Therapeutic Range -- 1.6 Summary -- Reference -- Chapter 2 Passage of Drugs Through Membranes -- 2.1 Introduction -- 2.2 Structure and Properties of Membranes -- 2.3 Passive Diffusion -- 2.4 Carrier-Mediated Processes: Transport Proteins -- References
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| 505 |
8 |
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|a Chapter 3 Drug Administration and Drug Absorption -- 3.1 Introduction: Local and Systemic Drug Administration -- 3.2 Routes of Drug Administration -- 3.3 Overview of Oral Absorption -- 3.4 Extent of Drug Absorption -- 3.5 Determinants of the Fraction of the Dose Absorbed (F) -- 3.6 Factors Controlling the Rate of Drug Absorption -- 3.7 Biopharmaceutics Classification System -- 3.8 Food Effects -- Problems -- References -- Chapter 4 Drug Distribution -- 4.1 Introduction -- 4.2 Extent of Drug Distribution -- 4.3 Rate of Drug Distribution -- 4.4 Distribution of Drugs to the Central Nervous System
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| 505 |
8 |
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|a Problems -- Note -- References -- Chapter 5 Drug Elimination and Clearance -- 5.1 Introduction -- 5.2 Clearance -- 5.3 Renal Clearance -- 5.4 Hepatic Elimination and Clearance -- Problems -- References -- Chapter 6 Compartmental Models in Pharmacokinetics -- 6.1 Introduction -- 6.2 Expressions for Component Parts of the Dose-Plasma Concentration Relationship -- 6.3 Putting Everything Together: Compartments and Models -- 6.4 Examples of Complete Compartment Models -- 6.5 Use of Compartmental Models to Study Metabolite Pharmacokinetics -- 6.6 Selecting and Applying Models -- Problems
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| 505 |
8 |
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|a Suggested Readings -- Chapter 7 Pharmacokinetics of an Intravenous Bolus Injection in a One-Compartment Model -- 7.1 Introduction -- 7.2 One-Compartment Model -- 7.3 Pharmacokinetic Equations -- 7.4 Simulation Exercise -- 7.5 Application of the Model -- 7.6 Determination of Pharmacokinetic Parameters Experimentally -- 7.7 Pharmacokinetic Analysis in Clinical Practice -- Problems -- Suggested Reading -- Chapter 8 Pharmacokinetics of an Intravenous Bolus Injection In A Two-Compartment Model -- 8.1 Introduction -- 8.2 Tissue and Compartmental Distribution of a Drug -- 8.3 Basic Equation
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| 505 |
8 |
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|a 8.4 Relationship Between Macro and Micro Rate Constants -- 8.5 Primary Pharmacokinetic Parameters -- 8.6 Simulation Exercise -- 8.7 Determination of the Pharmacokinetic Parameters of the Two-Compartment Model -- 8.8 Clinical Application of the Two-Compartment Model -- Problems -- Suggested Readings -- Chapter 9 Pharmacokinetics of Extravascular Drug Administration -- 9.1 Introduction -- 9.2 First-Order Absorption in a One-Compartment Model -- 9.3 Modified Release and Gastric Retention Formulations -- 9.4 Bioavailability -- 9.5 IN VITRO-IN VIVO Correlation -- 9.6 Simulation Exercise -- Problems
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| 504 |
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|a References
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 655 |
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0 |
|a Electronic books.
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| 758 |
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|i has work:
|a Basic pharmacokinetics and pharmacodynamics (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGqjfDrbPfYRbKwTvVJr9C
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|a Rosenbaum, Sara E.
|t Basic Pharmacokinetics and Pharmacodynamics
|d Newark : John Wiley & Sons, Incorporated,c2016
|z 9781119143154
|
| 830 |
|
0 |
|a New York Academy of Sciences Ser.
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=7104454
|z Texto completo
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| 938 |
|
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|a ProQuest Ebook Central
|b EBLB
|n EBL7104454
|
| 994 |
|
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|a 92
|b IZTAP
|
