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20240329122006.0 |
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230209s2013 xx o ||| 0 eng d |
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|a EBLCP
|b eng
|c EBLCP
|d OCLCQ
|d EBLCP
|d OCLCO
|d OCLCQ
|d OCLCL
|d OCLCQ
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| 020 |
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|a 9781118354421
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|a 1118354427
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|a (OCoLC)1347028178
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|a 615.1/9
|q OCoLC
|2 23/eng/20230216
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|a UAMI
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| 100 |
1 |
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|a Li, Jie Jack.
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| 245 |
1 |
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|a Heterocyclic Chemistry in Drug Discovery
|h [electronic resource].
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| 260 |
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|a Newark :
|b John Wiley & Sons, Incorporated,
|c 2013.
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| 300 |
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|a 1 online resource (722 p.).
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| 490 |
1 |
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|a New York Academy of Sciences Ser.
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| 500 |
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|a Description based upon print version of record.
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0 |
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|a Cover -- Title Page -- Copyright Page -- Contents -- Preface -- Contributing Authors -- Chapter 1 Introduction -- 1.1 Nomenclature of Heterocycles -- 1.2 Aromaticity of Heterocycles -- 1.3 Importance of Heterocycles in Life -- 1.4 Importance of Heterocycles in Drug Discovery -- 1.4.1 Five-Membered Heterocycles with One Heteroatom -- 1.4.2 Five-Membered Heterocycles with Two Heteroatoms -- 1.4.3 Six-Membered Heterocycles with One Heteroatom -- 1.4.4 Six-Membered Heterocycles with Two Heteroatoms -- PART I FIVE-MEMBERED HETEROCYCLES WITH ONE HETEROATOM -- Chapter 2 Pyrroles -- 2.1 Introduction
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| 505 |
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|a 2.2 Reactivity of the Pyrrole Ring -- 2.2.1 Protonation -- 2.2.2 C2 Electrophilic Substitution -- 2.2.3 C3 Electrophilic Substitution -- 2.2.4 Metalation -- 2.3 Construction of the Pyrrole Rings -- 2.3.1 Knorr Pyrrole Synthesis -- 2.3.2 Paal-Knorr Pyrrole Synthesis -- 2.3.3 Hantsch Pyrrole Synthesis -- 2.3.4 Barton-Zard Reaction -- 2.4 Palladium Chemistry of Pyrroles -- 2.5 Possible Liabilities of Pyrrole-Containing Drugs -- 2.6 Problems -- 2.7 References -- Chapter 3 Indoles -- 3.1 Introduction -- 3.2 Reactivity of the Indole Ring -- 3.2.1 Protonation -- 3.2.2 C3 Electrophilic Substitution
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| 505 |
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|a 3.2.3 C2 Electrophilic Substitution -- 3.2.4 Metallation -- 3.3 Construction of the Indole Rings -- 3.3.1 Fischer Indole Synthesis -- 3.3.2 Mori-Ban Indole Synthesis -- 3.3.3 Larock Indole Synthesis -- 3.3.4 Bischler-Möhlau Indole Synthesis -- 3.3.5 Nenitzescu Indole Synthesis -- 3.3.6 Bartoli Indole Synthesis -- 3.3.7 Batcho-Leimgruber Indole Synthesis -- 3.3.8 Gassman Indole Synthesis -- 3.3.9 Cadogan-Sundberg Indole Synthesis -- 3.4 Oxindole-containing Drug Synthesis -- 3.5 Cross-coupling Reactions for Indoles -- 3.5.1 Palladium-Catalyzed Oxidative Coupling -- 3.5.2 Negishi Coupling
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| 505 |
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|a 3.5.3 Suzuki Coupling -- 3.5.4 Sonogashira Coupling -- 3.5.5 Heck Reaction -- 3.6 Azaindoles -- 3.6.1 Larock Reaction -- 3.6.2 Bartoli Reaction -- 3.6.3 Batcho-Leimgruber Reaction -- 3.6.4 Cadogan-Sundberg Indole Synthesis -- 3.7 Possible Liabilities of Drugs Containing 3-Methylindole -- 3.8 Problems -- 3.9 References -- Chapter 4 Furans, Benzofurans, Thiophenes, and Benzothiophenes -- 4.1 Introduction -- 4.2 Furans and Benzofurans -- 4.2.1 Reactions of Furans and Benzofurans -- 4.2.2 Furan and Benzofuran Synthesis -- 4.2.3 Synthesis of Furan- and Benzofuran-Containing Drugs
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| 505 |
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|a 4.3 Thiophenes and Benzothiophenes -- 4.3.1 Reactions of Thiophene and Benzothiophene -- 4.3.2 Synthesis of Thiophene and Benzothiophene -- 4.3.3 Synthesis of Thiophene- and Benzothiophene-Containing Drugs -- 4.4 Possible Liabilities of Furan- and Thiophene-Containing Drugs -- 4.5 Problems -- 4.6 References -- PART II FIVE-MEMBERED HETEROCYCLES WITH TWO OR MORE HETEROATOMS -- Chapter 5 Pyrazoles, Pyrazolones, and Indazoles -- 5.1 Introduction -- 5.1.1 Basicity and Acidity -- 5.1.2 Tautomerization -- 5.2 Reactivities of the Pyrazole Ring -- 5.2.1 Alkylation of the Pyrazole Ring
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| 500 |
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|a 5.2.2 C4 Electrophilic Substitution
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 655 |
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0 |
|a Electronic books.
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| 758 |
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|i has work:
|a Heterocyclic chemistry in drug discovery (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGBGmbrdCTRp9kgX7jVbJP
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|a Li, Jie Jack
|t Heterocyclic Chemistry in Drug Discovery
|d Newark : John Wiley & Sons, Incorporated,c2013
|z 9781118148907
|
| 830 |
|
0 |
|a New York Academy of Sciences Ser.
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=7103576
|z Texto completo
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| 938 |
|
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|a ProQuest Ebook Central
|b EBLB
|n EBL7103576
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| 994 |
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|a 92
|b IZTAP
|
