General and Molecular Pharmacology Principles of Drug Action.

Detalles Bibliográficos
Autor principal: Clementi, Francesco
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Newark : John Wiley & Sons, Incorporated, 2015.
Colección:New York Academy of Sciences Ser.
Temas:
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Title Page
  • Copyright Page
  • Contents
  • List of Contributors
  • Preface
  • SECTION 1 INTRODUCTION TO PHARMACOLOGY
  • CHAPTER 1 ESSENTIAL LEXICON OF PHARMACOLOGY
  • THE SOCIAL IMPACT OF PHARMACOLOGY
  • ESSENTIAL LEXICON
  • Active Substances
  • Pharmacological Disciplines
  • Drug-Receptor Interactions
  • Measure of the Clinical Response
  • TAKE-HOME MESSAGE
  • CHAPTER 2 A SHORT HISTORY OF PHARMACOLOGY
  • BIRTH AND HISTORICAL DEVELOPMENTS OF PHARMACOLOGY
  • From Magical and Natural Remedies of Ancient Medicine to Arabic Alchemy
  • From Monastic Medicine to Botanical Gardens
  • From Anatomical Renaissance to the "Experienz": Paracelsus' Spagyric
  • From Iatrochemistry to the Age of Enlightenment
  • From the Search of the Active Principle to the Discovery of Alkaloids and Glucosides
  • The Drug Synthesis Revolution: From Handmade to Industrial Production
  • MODERN PHARMACOLOGY
  • Ehrlich and Chemotherapy: The Concept of Receptor
  • The Birth of Modern Pharmacology
  • THE BIOTECHNOLOGY ERA AND THE PHARMACOLOGY IN THE THIRD MILLENNIUM
  • The Impact of New Biotechnologies: Molecular Biology, Bioinformatics, and Combinatorial Chemistry
  • Biological Drugs and Pharmacology Perspectives
  • Personalized Therapies and New Sceneries in Pharmaceutical Industry
  • TAKE-HOME MESSAGE
  • FURTHER READING
  • SECTION 2 GETTING THE DRUG TO ITS SITE OF ACTION
  • CHAPTER 3 CELLULAR BASIS OF PHARMACOKINETICS
  • A QUICK JOURNEY WITH THE DRUG IN THE BODY
  • Absorption
  • Distribution
  • Drug Elimination
  • CROSSING CELL MEMBRANES
  • Passive Diffusion across Cell Membranes
  • Drug Transport across Cell Membranes
  • Endocytosis
  • DRUG DIFFUSION TO ORGANS AND TISSUES
  • Properties of the Most Important Cell Barriers
  • TAKE-HOME MESSAGE
  • FURTHER READING
  • CHAPTER 4 DRUG ABSORPTION AND ADMINISTRATION ROUTES
  • GENERAL RULES ABOUT DRUG ABSORPTION RATE
  • Partition Coefficient
  • Drug Dispersion
  • Extension of the Absorbing Surface
  • Permeability of the Absorbing Surface
  • Vascularization
  • ENTERAL ROUTES OF ADMINISTRATION
  • Oral Route
  • Sublingual and Rectal Routes
  • SYSTEMIC PARENTERAL ROUTES OF ADMINISTRATION
  • The Intravascular Route
  • i.m. Injection
  • Subcutaneous and Intradermal Injections
  • OTHER ROUTES OF DRUG ADMINISTRATION
  • Inhalation Route
  • Topical/Regional Routes
  • Intracavity Routes
  • Dermal or Transcutaneous Route
  • Mucosal Routes
  • ABSORPTION KINETICS
  • General Rules
  • Interrelation between Gene Therapy and Drug Delivery Techniques
  • TAKE-HOME MESSAGE
  • FURTHER READING
  • CHAPTER 5 DRUG DISTRIBUTION AND ELIMINATION
  • DISTRIBUTION
  • Tissues and Avidity for Drugs
  • The Apparent Distribution Volume
  • Drug Binding to Plasma Proteins
  • Factors That Determine the Distribution Rate of Drugs to the Various Compartments
  • ELIMINATION
  • The Concept of Half-Life
  • The Concept of Clearance
  • RENAL EXCRETION OF DRUGS
  • Glomerular Filtration

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