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| LEADER |
00000cam a2200000Mu 4500 |
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EBOOKCENTRAL_on1347023228 |
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OCoLC |
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20240329122006.0 |
| 006 |
m o d |
| 007 |
cr cnu|||||||| |
| 008 |
230209s2002 xx o ||| 0 eng d |
| 040 |
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|a EBLCP
|b eng
|c EBLCP
|d OCLCQ
|d EBLCP
|d OCLCQ
|d OCLCO
|d OCLCQ
|d OCLCL
|d OCLCQ
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| 020 |
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|a 9781405146067
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| 020 |
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|a 1405146060
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| 035 |
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|a (OCoLC)1347023228
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| 082 |
0 |
4 |
|a 615.1
|q OCoLC
|2 23/eng/20230216
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| 049 |
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|a UAMI
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| 100 |
1 |
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|a Griffin, John.
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| 245 |
1 |
0 |
|a Textbook of Pharmaceutical Medicine
|h [electronic resource].
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| 260 |
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|a Newark :
|b Blackwell Publishing Ltd.,
|c 2002.
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| 300 |
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|a 1 online resource (896 p.).
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| 490 |
1 |
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|a New York Academy of Sciences Ser.
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| 500 |
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|a Description based upon print version of record.
|
| 505 |
0 |
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|a Intro -- Contents -- Contributors -- Preface -- Acknowledgements -- The editors -- Part I: Research and development -- 1: Discovery of new medicines -- 1.1 Introduction -- 1.2 Historical aspects -- 1.2.1 Early discoveries -- 1.3 Impact of new technology on drug discovery -- 1.3.1 Receptor subtypes -- 1.3.2 Genomics -- 1.3.3 Pharmacogenomics -- 1.3.4 Proteomics -- 1.3.5 Bioinformatics and data mining technologies -- 1.3.6 Combinatorial chemistry and high-throughput screening -- 1.3.6.1 Combinatorial synthesis -- 1.3.6.2 Library design -- 1.3.7 Structure-based drug design
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| 505 |
8 |
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|a 1.3.8 Virtual screening -- 1.3.9 NMR, x ray and mass spectroscopic techniques -- 1.3.10 Pharmacokinetics -- 1.4 Examples of drug discovery -- 1.4.1 Receptor ligands (agonists and antagonists) -- 1.4.1.1 Early examples -- 1.4.1.2 Selective oestrogen receptor modulators (oestrogen antagonists and aromatase inhibitors) -- 1.4.1.3 LHRH agonists and antagonists -- 1.4.1.4 Somatostatin agonists and antagonists -- 1.4.1.5 Angiotensin agonists and antagonists (peptides and non-peptides) -- 1.4.1.6 Bombesin/neuromedin agonists and antagonists -- 1.4.1.7 Bradykinin agonists and antagonists
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| 505 |
8 |
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|a 1.4.1.8 Cholecystokinin agonists and antagonists -- 1.4.1.9 Endothelin antagonists -- 1.5 Enzyme inhibitors -- 1.5.1 Converting enzyme inhibitors -- 1.5.2 Aspartyl protease (renin and HIV protease) inhibitors -- 1.5.2.1 Renin inhibitors -- 1.5.2.2 HIV protease inhibitors -- 1.5.3 Thrombin inhibitors (serine protease) -- 1.5.4 Ras protein farnesyltransferase inhibitors -- 1.5.5 Protein kinase inhibitors -- 1.6 Protein-protein interaction inhibitors -- 1.6.1 a4ß1 and a5ß1 antagonists -- 1.7 Summary -- References -- 2: Pharmaceutical development -- 2.1 Introduction -- 2.2 Preformulation
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| 505 |
8 |
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|a 2.2.1 Structure determination -- 2.2.2 Analytical development -- 2.2.3 Salt form -- 2.2.4 Chemical stability -- 2.2.5 Physicochemical properties -- 2.2.6 Chiral properties -- 2.2.7 Biopharmaceutical properties -- 2.2.8 Physical properties of the solid drug -- 2.2.9 Excipient compatibility -- 2.3 Formulation -- 2.3.1 Liquid formulations -- 2.3.2 Semi-solid formulations -- 2.3.3 Solid formulations -- 2.3.4 Contemporary formulationsa -- 2.3.5 Packaging -- 2.3.6 Stability testing -- 2.3.7 Scale-up and manufacture -- 2.3.8 Bioequivalence -- 2.4 Clinical trial supplies -- 2.4.1 Blinding
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| 505 |
8 |
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|a 2.4.2 Labelling of clinical trial materials -- 2.4.3 Quality assurance of clinical trial supplies -- 2.5 Conclusions -- Further reading -- References -- 3: Toxicity testing -- 3.1 Introduction -- 3.1.2 The drug development process -- 3.1.3 Risk benefit -- 3.2 Preclinical safety pharmocology -- 3.2.1 Introduction -- 3.2.2 Regulatory guidelines -- 3.2.3 General considerations -- 3.2.4 Experimental design -- 3.2.4.1 Controls -- 3.2.4.2 Route -- 3.2.4.3 Dose levels in vivo -- 3.2.4.4 Dose levels in vitro -- 3.2.5 Safety pharmacology core battery -- 3.2.5.1 Central nervous system
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| 500 |
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|a 3.2.5.2 Cardiovascular system
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| 590 |
|
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
|
| 655 |
|
0 |
|a Electronic books.
|
| 758 |
|
|
|i has work:
|a The textbook of pharmaceutical medicine (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCH4QQ6bpxcXWmKMFrcGHyd
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|a Griffin, John
|t Textbook of Pharmaceutical Medicine
|d Newark : Blackwell Publishing Ltd.,c2002
|z 9780727915238
|
| 830 |
|
0 |
|a New York Academy of Sciences Ser.
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=7104542
|z Texto completo
|
| 938 |
|
|
|a ProQuest Ebook Central
|b EBLB
|n EBL7104542
|
| 994 |
|
|
|a 92
|b IZTAP
|
