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Genomes, Evolution, and Culture Past, Present, and Future of Humankind.
| Autor principal: | |
|---|---|
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Newark :
John Wiley & Sons, Incorporated,
2016.
|
| Colección: | New York Academy of Sciences Ser.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Genomes, Evolution,and CulturePast, Present, and Futureof Humankind
- Contents
- Preface
- Chapter 1: The history of human evolutionary genetics
- World views
- Science and philosophy
- The biology of mankind: anatomy and physiology in a historical context (up to the 16th century)
- Beginnings of the present scientific model
- Biological evolution and genetic foundations: the brilliant quartet
- Nineteenth century: cytology, embryology, and reproduction
- Twentieth century, the century of genetics
- The synthetic theory of evolution
- Bacterial and molecular genetics
- Parallel developments: paleoanthropology
- Technical and methodological developments
- Conclusions
- Review questions and exercises
- References
- Chapter 2: The human genome: structure, function, and variation
- Science, politics, and ethics
- Structural aspects
- Normal and abnormal phenotype distribution
- Function
- Sex chromosomes
- Paleogenomics
- Variability: mtDNA
- Nuclear variability
- Exomes and proteomes
- Selection or drift? History
- Selection or drift? Methods
- Selection or drift? Analyses
- Nervous system and culture
- Conclusions
- Review questions and exercises
- References
- Chapter 3: Population structure
- DNA-based marker systems
- SNPs, STRs, and Indels as DNA markers
- SNPs
- STRs
- Indels
- Population genetic tools for analyzing population structure
- Forces affecting population dynamics, structure, and evolution
- Selection
- Genetic drift
- Migration and founder effect
- Isolation and inbreeding
- Nonrandom mating
- Bottlenecks
- Admixture
- Applications of population genetics
- Introduction
- Medicine
- Pharmacogenetics
- DNA fingerprinting
- From populations to races and species
- Review questions and exercises
- References
- Chapter 4: Genetic variability
- On the nature of variability
- Mechanisms responsible for generating genetic variability
- Randomness of mutations
- Inheritance and environment
- Selection works on the phenotype
- The impact of selection
- Cultural expressions as markers of ancestry
- Congruency among marker systems
- Does junk DNA exist?
- How genetic diversity is studied?
- Epigenetic diversity
- Review questions and exercises
- References
- Chapter 5: Gene and genomic dynamics
- Molecular evidence for punctuated equilibrium and gradualism
- Next-generation sequencing
- Genetic variation
- Variation, population structure, and effective population size
- Recombination and its effect on variation
- Linkage equilibrium and disequilibrium
- Forces leading to linkage disequilibrium
- Linkage disequilibrium and SNP haplotypes
- Linkage disequilibrium in humans
- Genome structural variations
- CNV classifications and formation mechanisms
- Methods used to detect CNVs
- CNVs associated with human phenotypes
- CNVs and evolution
- CNV in primates