Hemisynthesis of phenolic metabolites

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Straßmann, Sarah
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Göttingen : Cuvillier Verlag, 2021.
Colección:Schriftenreihe der Professur für Molekulare Lebensmitteltechnologie.
Temas:
Polyphenols.
Metabolites.
Anthocyanins.
Polyphénols.
Métabolites.
Anthocyanes.
Anthocyanins
Metabolites
Polyphenols
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Preliminary remarks
  • List of abbreviations
  • List of publications
  • Conferences
  • Declaration of contribution as co-author
  • Chapter 1 General Introduction
  • 1 Polyphenols
  • 2 Anthocyanins
  • 2.3 Physiological properties
  • 3 Synthesis of phase II metabolites
  • 3.1 Enzymatic synthesis
  • 3.2 Chemical synthesis
  • 3.3 Microbial synthesis
  • 4 Analysis and Characterization of the metabolites
  • 4.1 UV/Vis spectra
  • 4.2 Mass spectrometry
  • 4.3 Purification
  • 5 Aims of the thesis
  • Chapter 2 Hemisynthesis of Anthocyanin Phase II Metabolites byPorcine Liver Enzymes
  • 1 Introduction
  • 2 Materials and methods
  • 2.1 Chemicals
  • 2.2 Isolation of anthocyanins
  • 2.3 Preparation of liver fractions
  • 2.4 Incubation
  • 3 Results and discussion
  • 3.1 Methylation
  • 3.2 Glucuronidation
  • 3.3 Sulfation
  • 3.4 Multiple Conversions
  • 4 References
  • Chapter 3 Chemical Hemisynthesis of Sulfated Cyanidin-3-OGlucosideand Cyanidin Metabolites
  • 1 Introduction
  • 2 Results and discussion
  • 2.1 Cyanidin Sulfates
  • 2.2 Cyanidin-3-O-Glucoside Sulfates
  • 2.3 Challenges
  • 2.4 Human Pilot Study
  • 3 Materials and methods
  • 3.1 Chemicals
  • 3.2 Hemisynthesis of Sulfated Metabolites
  • 3.3 LC-MS-Analysis
  • 3.4 Study Design and Analysis of Urine
  • 4 Conclusions
  • 5 References
  • Chapter 4 Methylation of Cyanidin-3-O-Glucoside with DimethylCarbonat e
  • 1 Introduction
  • 2 Results and discussion
  • 2.1 First Observations
  • 2.2 Experimental Design
  • 2.3 Increase in Solvation of Anthocyanins
  • 2.4 Identification
  • 3 Materials and methods
  • 3.1 Chemicals
  • 3.2 Hemisynthesis
  • 3.3 LC-MS Analysis
  • 4 Conclusion
  • 5 References
  • Chapter 5 Concluding remarks
  • 1 Impact of contributions
  • 2 Remaining challenges and future directions
  • 3 References
  • Summary
  • Zusammenfassung
  • Acknowledgement

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