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Pizzo and Poplack's Pediatric Oncology
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Philadelphia :
Wolters Kluwer Health,
2020.
|
| Edición: | 8th ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Title Page
- Copyright Page
- Section 1 Biological Basis of Childhood Cancer
- 1 Epidemiology of Childhood Cancer
- Cancer Surveillance and Descriptive Epidemiology
- Analytic Epidemiology
- Summary and Future Considerations
- 2 Heredity and Childhood Cancer
- Constitutional Chromosomal Abnormalities
- Structural Chromosomal Abnormalities
- Overgrowth Disorders and Imprinting Errors
- Autosomal Dominant Disorders
- Autosomal Recessive Disorders
- Issue in Genetic Testing for the Pediatric Oncology Patient
- 3 Molecular and Genetic Basis of Childhood Cancer
- General Nature of Cancer-Associated Genetic Aberrations
- Comprehensive Analysis of the Cancer Genome
- Germline Mutations
- Somatically Acquired Chromosomal Aberrations and Mutation
- Gross Chromosomal Rearrangements
- Oncogenic Consequences of Gross Chromosomal Rearrangements-General Themes
- Chromosomal Translocations Lead to Activation of Proto-Oncogenes and Generation of Oncogenic Fusion Genes
- Chromosomal Deletion Leads to Inactivation of Tumor Suppressor Genes
- Gene Amplification
- Point Mutations Leading to Gene Activation or Inactivation
- Comprehensive Genomic Studies of Pediatric Tumors
- Mechanisms of Malignant Cell Transformation, Growth, and Clonal Expansion
- Outlook for Molecularly Targeted Therapies
- Summary
- 4 Biology of Childhood Cancer
- Gene Regulation
- Protein Regulation
- Signal Transduction
- Cell Proliferation
- Programmed Cell Death
- Cancer Metabolism
- Metastasis and the Tumor Microenvironment
- 5 Tumor Immunology of Childhood Cancer
- Overview of the Immune System
- Modern Concepts of Immune Surveillance
- T-Cell Recognition of Cancer
- Innate Immune Cells and the Tumor Microenvironment
- Immune Function in Cancer Patients
- Immunotherapy of Cancer
- Summary and Future Directions
- Section 2 Diagnosis and Evaluation of the Child with Cancer
- 6 Clinical Assessment and Differential Diagnosis of Suspected Childhood Cancer
- Children at Risk
- Time to Diagnosis
- Differential Diagnosis
- Establishing the Diagnosis
- Summary
- 7 Pathology and Molecular Diagnosis of Leukemias and Lymphomas
- Introduction
- Ancillary Studies
- Lymphoblastic Leukemia
- Myeloid Neoplasms
- Mature Lymphoid Neoplasms
- Histiocytic Disorders
- 8 Diagnostic Pathology of Pediatric Solid and Central Nervous System Malignancies
- Introduction
- Brief Pathologic Classification of Pediatric Solid Tumors
- Traditional Approaches to Childhood Solid Tumor Diagnosis
- Molecular Genetic Evaluation of Childhood Cancer
- Integrated Diagnostic Molecular Pathology of Pediatric Solid Tumors
- The Holistic Cancer Genome
- DNA
- RNA
- Emerging Technologies for Diagnosis
- The Future of Pediatric Cancer Diagnosis
- 9 Imaging Studies in the Diagnosis of Childhood Cancer
- Relative Merits of Available Imaging Procedures