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Hot topics in cardio-oncology /
Over the last years, thanks to growing advances in the field of cancer therapies, a considerable decrease in cancer mortality has been observed. Unfortunately, such therapies have shown a wide spectrum of cardiotoxicities. This book provides the readers with the latest advances and insights in the e...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[Place of publication not identified] :
River Publishers,
2021.
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| Colección: | River Publishers series in biotechnology and medical technology forum.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Hot topics in cardio-oncology / |c [edited by] Valentina Mercurio [and more]. |
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| 490 | 1 | |a River Publishers series in biotechnology and medical technology forum | |
| 520 | |a Over the last years, thanks to growing advances in the field of cancer therapies, a considerable decrease in cancer mortality has been observed. Unfortunately, such therapies have shown a wide spectrum of cardiotoxicities. This book provides the readers with the latest advances and insights in the ever-expanding field of Cardio-Oncology. Specific topics discussed in the book include the potential role of inflammation in Cardio-Oncology and the description of the different manifestations of cardiotoxicities (including vascular toxicity, systemic hypertension, arrhythmias), analyzing the complex relationships between cancer and heart failure, two conditions whose prevalence increases with ageing. Furthermore, the role of biomarkers and imaging in cardio-oncology is discussed. | ||
| 505 | 0 | |a List of Figures ix List of Tables xi List of Contributors xiii List of Abbreviations xvii Introduction xxi 1 Inflammation in Cardio-Oncology 1 1.1 Introduction 2 1.2 Inflammation in Cardiac Injury and Repair 2 1.3 Immune Checkpoint Inhibitors 4 1.4 CAR-T Cell Therapy 8 1.5 Inflammation at the Crossroad Between Cancer and Cardiovascular Diseases 9 References 12 2 Vascular Toxicity and Thromboembolic Risk in Cardio-Oncology 21 2.1 Introduction 21 2.2 Acute Coronary Syndrome (ACS) and Coronary Artery Diseases (CAD) 22 2.3 Other Drugs that Cause Myocardial Infarction and Coronary Artery Diseases 25 2.4 Arterial Hypertension 27 2.5 Peripheral Artery Occlusive Diseases 28 2.6 Pulmonary Hypertension 29 2.7 Stroke 29 2.8 Thromboembolic Risk and Atrial Fibrillation 30 2.9 Prevention and Treatment of Vascular Toxicity 31 References 32 3 Hypertensive Oncologic Patients 41 3.1 Introduction 41 3.2 Implications of Arterial Hypertension in Patients Undergoing Anticancer Treatments 42 3.2.1 Anthracyclines 42 3.2.2 Carfilzomib 42 3.2.3 Anti-vascular endothelial growth factor agents 43 3.3 Management of Arterial Hypertension in Oncologic Patients 44 References 47 4 Cardiac Surgery and Percutaneous Coronary Intervention in Patients With Cancer 51 4.1 Introduction 51 4.1.1 The complex interplay between ACS and cancer: bench and pharmacological data 51 4.1.2 The complex interplay between ACS and cancer: the role of the disease 52 4.1.3 The complex interplay between ACS and cancer: the role of chemotherapy and of radiotherapy 53 4.1.4 The complex interplay between ACS and cancer: clinical data 55 4.1.5 The complex interplay between cardiac surgery and cancer: clinical data 57 References 58 5 Cancer Therapy-Induced Arrhythmias 63 5.1 Introduction 63 5.1.1 Epidemiology 63 5.1.2 Etiology and Pathogenesis 64 5.1.3 Diagnosis, Physical Examination, and Diagnostic Tests 67 5.1.4 Clinical Characteristics 69 5.1.5 Treatment 69 5.1.6 Prophylaxis 76 References 78 6 Cancer in the Heart Failure Population 83 6.1 Introduction 84 6.2 Heart Failure and New Onset Cancer: Epidemiology 84 6.3 Mechanisms of Cancer Development in the Heart Failure Population 87 6.4 Cancer in Heart Failure Patients: Clinical Implications 91 6.5 Conclusions 96 References 97 7 Metabolomics in the Identification of New Biomarkers in Cardio-Oncology 107 7.1 Introduction 107 7.2 Metabolomics 108 7.3 Metabolomics in Cardio-Oncology 110 7.4 Metabolomics Profiling Cardioprotective Strategies 114 7.5 Conclusion 115 References 116 8 Imaging in Cardio-Oncology 121 8.1 Introduction 121 8.2 Conventional Echocardiography 122 8.2.1 LV systolic and diastolic function 122 8.2.2 RV function 124 8.2.3 Valvular heart disease 125 8.2.4 Pericardial disease 126 8.3 Advanced Echocardiography 127 8.3.1 Myocardial deformation imaging 127 8.4 Three-Dimensional Echocardiography (3DE) 129 8.5 Assessment of Cardiotoxicity Risk and Echocardiographic Surveillance According to Anticancer Treatment 129 8.6 Other imaging modalities 133 8.6.1 Cardiac Magnetic Resonance 133 8.7 Cardiac Nuclear Imaging 135 8.8 Multimodality Imaging in Screening and Follow-up in Radiotherapy 136 8.8.1 Pericardial disease 136 8.8.2 Myocardial dysfunction 136 8.8.3 Valvular heart disease (see also above) 137 8.8.4 Coronary artery disease 137 8.9 Conclusions and Future Directions 138 References 139 9 Venous Thromboembolism in Cardio-Oncology 147 9.1 Introduction 147 9.2 Biological Mechanism of Cancer-Related Thrombosis 148 9.3 Epidemiology and Risk Stratification 148 9.4 Clinical Presentation 151 9.5 Recurrent Venous Thrombosis and Treatment in Cancer Population 153 9.6 Prognosis 155 9.7 Thromboprophylaxis 155 9.8 Conclusions 156 References 157 Conclusions and Remarks 163 References 164 Index 165 About the Editors 167. | |
| 500 | |a Includes index. | ||
| 588 | 0 | |a Print version record. | |
| 545 | 0 | |a Valentina Mercurio, Pasquale Pagliaro, Claudia Penna, Carlo Gabriele Tocchetti | |
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Heart |x Diseases. | |
| 650 | 0 | |a Cardiovascular toxicology. | |
| 650 | 0 | |a Cancer |x Treatment |x Complications. | |
| 650 | 2 | |a Heart Diseases | |
| 650 | 6 | |a Cœur |x Maladies. | |
| 650 | 6 | |a Toxicologie cardiovasculaire. | |
| 650 | 6 | |a Cancer |x Traitement |x Complications et séquelles. | |
| 650 | 7 | |a MEDICAL / Oncology |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Cardiology |2 bisacsh | |
| 650 | 7 | |a Cancer |x Treatment |x Complications |2 fast | |
| 650 | 7 | |a Cardiovascular toxicology |2 fast | |
| 650 | 7 | |a Heart |x Diseases |2 fast | |
| 700 | 1 | |a Mercurio, Valentina, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t HOT TOPICS IN CARDIO-ONCOLOGY. |d [Place of publication not identified] : RIVER PUBLISHERS, 2021 |z 8770226288 |w (OCoLC)1255691416 |
| 830 | 0 | |a River Publishers series in biotechnology and medical technology forum. | |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=6705001 |z Texto completo |
| 938 | |a Askews and Holts Library Services |b ASKH |n AH40583832 | ||
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