Detection of pathogenic infections in neurological disorders through recycling of gene expression data

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Liebhoff, Anna-Maria
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Göttingen : Cuvillier Verlag, 2021.
Temas:
RNA viruses > Research > Methodology.
Virus à ARN > Recherche > Méthodologie.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • 1 Introduction
  • 2 Biological background
  • 2.1 Ribonucleic acid (RNA)
  • 2.2 Small RNA
  • 2.3 Sequencing
  • 2.4 Microbiology
  • 2.5 Neurodegenerative diseases
  • 2.6 Pathogens in neurological diseases
  • 3 Bioinformatics background
  • 3.1 Data sources
  • 3.2 Metadata and biological ontologies
  • 3.3 Read alignment
  • 3.4 Comparative analysis
  • 3.5 Metagenomic analysis
  • 3.6 Integrated analysis pipelines
  • 4 Computer science background
  • 4.1 Web development
  • 4.2 Data science and machine learning
  • 5 Small RNA Expression Atlas (SEA)
  • 5.1 Background
  • 5.2 System architecture
  • 5.3 Implementation
  • 5.4 System behavior
  • 5.5 Results
  • 6 Biological discoveries through SEA
  • 6.1 Tissue specificity of small RNA
  • 6.2 User data and Parkinson's disease
  • 6.3 Pathogens in neurodegenerative diseases
  • 6.4 Sex specificity of small RNA in human body
  • 6.5 Discussion
  • 7 Pathogen detection in RNA-seq data
  • 7.1 Background
  • 7.2 Identification algorithm
  • 7.3 Performance measures
  • 7.4 Evaluation
  • 8 Path(ogen)s to disease
  • 8.1 Analysis pipeline
  • 8.2 Burkholderia stabilis in frontotemporal dementia
  • 8.3 Discussion
  • 9 Conclusion
  • Bibliography
  • A SEA JSON communication objects
  • B Pathonoia algorithms
  • C Detailed analysis results

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