PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Li, Biaoru, Larson, Alan, Li, Shen
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Singapore : BENTHAM Science PUBLISHER, 2020.
Temas:
Cancer > Immunological aspects.
Cancer > Immunotherapy.
Tumors > Immunological aspects.
Cancer > Immunologie.
Cancer > Immunothérapie.
Tumeurs > Immunologie.
Cancer > Immunological aspects
Cancer > Immunotherapy
Tumors > Immunological aspects
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title
  • Copyright
  • End User License Agreement
  • Contents
  • Preface
  • REFERENCES
  • List of Contributors
  • INTRODUCTION
  • MHC and Cancer Immunotherapy
  • Li-Hua Jiang1,* and Wei-Hua Yan2
  • OVERVIEW OF MHC GENES AND MOLECULES
  • 1. Characteristics of the HLA Gene Complex
  • 2. HLA Molecule Structure
  • 3. Distribution and Function of HLA Molecules
  • 4. MHC Allele Detection
  • MHC CLASS I MOLECULAR LOSS AND CANCER IMMUNOTHERAPY
  • 1. Loss of Class I HLA Expression in Tumor Tissues
  • 2. Types of Class I HLA Deletion.
  • 3. Expression of Class I HLA Molecules and Efficiency of Immunotherapy
  • 4. The Relation Between Selective Pressure of Immunocyte and Changes of Class-I HLA Expression Pattern in Tumor Cells
  • EXPRESSION LEVELS OF NONCLASSICAL MHC CLASS I AND TUMOR IMMUNE ESCAPE
  • 1. The HLA Class I Antigen Expression and Cancer
  • 2. Roles of HLA Ib Antigens in Immune Modulation
  • 3. Clinical Relevance of HLA Ib Expression in Cancers
  • 4. Prospective of HLA-E and HLA-G Targeted Cancer Immunotherapy
  • MHC FOR T-CELL EPITOPE AND ACTIVE IMMUNE VACCINES
  • MHC FOR ADOPTIVE IMMUNE CELL THERAPY
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Immune Cells Signaling-Pathway and Genomic Profiles for Personalized Immunotherapy
  • Wei Zhang1, Yan Qu1, Meihua Lin1, Amit Datta1, George E. Liu1,2 and Biaoru Li1,3,*
  • INTRODUCTION
  • T-CELL MEMBRANE SIGNALING
  • T-CELLS PATHWAY AND NETWORKS
  • GENOMIC EXPRESSION PROFILE OF T-CELLS
  • 1. Genomic Expression Profiles of TIL
  • 2. Genomic Expression Profiles from Peripheral Blood Immune Cells
  • GENOMIC EXPRESSION PROFILE OF B-CELL
  • 1. Genomic Expression Profiles of B-Lymphocyte
  • 2. Network of B-lymphocyte
  • GENOMIC EXPRESSION PROFILE AND NETWORK OF NK-CELL
  • 1. NK-Lymphocyte
  • 2. Genomic Expression Profiles of NK-Lymphocyte
  • 3. Network of NK-Lymphocyte
  • GENOMIC EXPRESSION PROFILE OF NKT-CELL
  • 1. NKT-Lymphocyte
  • 2. Genomic Expression Profiles and Network of NKT-Lymphocyte
  • GENOMIC EXPRESSION PROFILE OF MACROPHAGE
  • 1. Macrophage
  • 2. Genomic Expression Profiles and Network of Macrophages
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Immunoassay of Personalized Immunotherapy
  • Li-Hua Jiang1 and Biaoru Li1,2,*
  • INTRODUCTION
  • BASIC RECORD OF IMMUNE FUNCTION AND RESPONSE
  • Delayed-Type Hypersensitivity In Vivo
  • Measures of Immune Function Ex Vivo
  • 1. Detection of T-cell Number with Intracellular Cytokines by Flow Cytometry
  • 2. Detection of Secreted Cytokines by ELISA Assays
  • 3. Lymphoproliferation Assay
  • 4. CTL and Quantifying CTL
  • Measures of Antigen-Specific Immune Responses In Vitro/Ex Vivo
  • 1. Peptide MHC Tetramers
  • 2. TCR Complementarity Determining Region
  • Measurement of Cytokine mRNA
  • Measurement of Tumor Antibodies
  • MEASUREMENT OF IMMUNE TARGETS FOR IMMUNOTHERAPY

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