Superparamagnetic iron oxide nanoparticles : synthesis, surface engineering, cytotoxicity, and biomedical applications /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Mahmoudi, Morteza, 1979-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Science Publishers, [2011]
Colección:Nanotechnology science and technology series.
Temas:
Nanomedicine.
Ferric oxide > Magnetic properties.
Nanoparticles.
Nanoparticles
Nanomedicine
Nanoparticules.
Nanomédecine.
MEDICAL > Instruments & Supplies.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES: SYNTHESIS, SURFACE ENGINEERING, CYTOTOXICITY AND BIOMEDICAL APPLICATIONS
  • SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES: SYNTHESIS, SURFACE ENGINEERING, CYTOTOXICITY AND BIOMEDICAL APPLICATIONS
  • LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA
  • DEDICATION
  • ABOUT THE AUTHORS
  • CONTENTS
  • PREFACE
  • Chapter 1 INTRODUCTORY TO THE BOOK
  • 1.1. SEMICONDUCTING NANOPARTICLES
  • 1.2. IRON OXIDE NANOPARTICLES
  • 1.3. BIOMINERALIZATION
  • 1.4. TYPES OF MAGNETIC IRON OXIDES
  • 1.5. SYNTHESIS OF SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (SPIONS): CHEMICAL COPRECIPITATION
  • 1.6. DESIGN OF EXPERIMENTS (DOE) FOR SYNTHESIS OF SPIONS
  • REFERENCES
  • Chapter 2 SYNTHESIS OF SPIONS
  • 2.1. NUCLEATION OF NANOPARTICLES
  • 2.2. SYNTHESIS METHODS
  • 2.2.1. Chemical Methods
  • 2.2.1.1. Co-precipitation
  • 2.2.1.2. Microemulsions
  • 2.2.1.3. Hydrothermal
  • 2.2.1.4. Thermal Decomposition
  • 2.2.1.5. Sol-gel
  • 2.2.1.6. Polyol
  • 2.2.1.7. Sonochemical
  • 2.2.1.8. Electrochemical Deposition
  • 2.2.2. Physical Methods
  • 2.2.2.1. Flow Injection
  • 2.2.2.2. Aerosol/Vapor
  • 2.2.2.3. Pulsed Laser Ablation
  • 2.2.2.4. Laser Induced Pyrolysis
  • 2.2.2.5. Powder Ball Milling
  • 2.2.3. Biological/ Bio-mineralization
  • REFERENCES
  • Chapter 3 APPLICATION OF STATISTICAL TECHNIQUES
  • 3.1. THE TWO SAMPLE T-TEST
  • 3.2. HYPOTHESIS TESTING FOR OUTLIER DETECTION
  • GRUBBS' TEST
  • 3.3. DESIGN OF EXPERIMENTS
  • Remark: How to Perform the Analysis with More than Two Factors, Two Levels?
  • 3.3.1. Checking Model Assumptions: Effect of Potentially Outlying Observations
  • REFERENCES
  • Chapter 4 COATINGS OF SPIONS
  • 4.1. COLLOIDAL STABILITY OF SPIONS
  • 4.2. POLYMERIC COATING
  • 4.2.1. Polyethylene Glycol
  • 4.2.2. Polyethylene Glycol Fumarate
  • 4.2.3. Polyvinyl Alcohol
  • 4.2.4. Polyacrylic Acid.
  • 4.2.5. Poly(N-isopropylacrylamide)
  • 4.2.6. Dextran
  • 4.2.7. Poly(D, L-lactide)
  • 4.2.8. Poly(D, L-lactide-co-glycolide)
  • 4.2.9. Alginate
  • 4.2.10. Chitosan and Polyethylenimine
  • 4.3. NON-POLYMERIC COATING
  • 4.3.1. Gold
  • 4.3.2. Silica
  • 4.4. FUNCTIONALIZATION OF SPIONS
  • REFERENCES
  • Chapter 5 CYTOTOXICITY OF SPIONS
  • 5.1. BIOCOMPATIBILITY VERSUS TOXICITY
  • 5.1.1. Biocompatibility
  • 5.1.2. Cytotoxicity
  • 5.2. IN VITRO TOXICITY ASSAYS
  • 5.2.1. Metabolic Activity
  • 5.2.1.1. MTT Assay
  • 5.2.1.1.1. Modification of MTT Method
  • 5.2.1.2. MTS and XTT Assays
  • 5.2.1.2.1. MTS Assay
  • 5.2.1.2.2. XTT Assay
  • 5.2.1.3. Redox Assay
  • 5.2.1.4. Adenosine Triphosphate Assay
  • 5.12.1.5. Cytochrome C Assay
  • 5.2.1.6. Nitroblue Tetrazolium (NBT) Assay
  • 5.2.1.7. WST Assay
  • 5.2.2. Membrane Integrity
  • 5.2.2.1. LDH Assay
  • 5.2.2.2. The Calcein AM, Live/Dead and Ethidium Homodimer Assay
  • 5.2.2.3. Dye Assays
  • 5.2.2.3.1. Erythrosine B (EB) Assay
  • 5.2.2.3.2. Propidium Iodide (PI) Assay
  • 5.2.2.3.3. Neutral Red (NR) Assay
  • 5.2.2.3.4. Bromodeoxyuridine (BrdU) Assay
  • 5.2.2.3.5. Trypan Blue (TB) Assay
  • 5.2.2.3.6. DNA Hoechst Assay
  • 5.2.2.3.7. Other Dye Assays
  • 5.2.3. Cell Proliferation Assay
  • 5.2.3.1. Cell Cycle Assay
  • 5.2.3.2. [3H] Thymidine Incorporation Assay
  • 5.2.4. Apoptosis Detection
  • 5.2.4.1. Flow Cytometry
  • 5.2.4.2. Comet Assay
  • 5.3. IN VIVO TOXICITY
  • 5.4. PHARMACOKINETICS AND BIODISTRIBUTION
  • REFERENCES
  • Chapter 6 APPLICATION OF SPIONS*
  • 6.1. SPIONS AS MAGNETIC RESONANCE IMAGING CONTRAST AGENT
  • Introduction
  • Paramagnetic Agents
  • Superparamagnetic Agents
  • Current Clinical Use of (U)SPIONs as Contrast Agents
  • Oral Contrast Agents
  • Injectable Contrast Agents
  • Ferumoxides (Feridex I.V./Endorem)
  • Ferucarbotran/SHU555A (Resovist/Cliavist)
  • Ferumoxtran-10 (USPIO) (Combidex/Senerem).
  • PEG-feron (Feruglose/Clariscan)
  • Ferucarbotran (USPIO)/SHU555C (Supravist)
  • Ferumoxytol (USPIO) (Feraheme)
  • 6.2. SPIONS FOR MAGNETIC LABELING OF CELLS
  • Introduction
  • SPIONs and its Modification for Labeling
  • Transfection Agents Mediated Modification of SPIONs for Cell Labeling
  • Optimization of Cell Labeling with Simple Incubation
  • Assay to Determine the Toxicity of Labeling
  • 6.3. SPIONS AND MAGNETICALLY LABELED CELLS FOR MULTIMODAL REGIMENS
  • SPIONs for Multimodal Imaging
  • Cells for Multimodal Imaging
  • 6.4. SPIONS AS DRUG DELIVERY VEHICLES
  • Introduction
  • Active Targeting Using Ligand Substrate Mechanisms, Antigen-Antibody or Receptors
  • Enhanced Permeability Retention (EPR) Effect
  • Convection-Enhanced Delivery
  • Magnet Activated Delivery
  • Drug Delivery by Direct Injection
  • 6.5. SPIONS FOR HYPERTHERMIA TREATMENT
  • 6.6. SPIONS FOR ENHANCED TRANSFECTION OF DNA (MAGNETOFECTION)
  • 6.7. SPIONS FOR CELL/PROTEIN SEPARATION
  • 6.8. SPIONS AS CATALYST
  • 6.9. SPIONS FOR TISSUE REPAIR
  • REFERENCES
  • INDEX.

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