Advances in metallodrugs preparation and applications in medicinal chemistry /

"Over the past few decades, medicinal inorganic chemistry as an interdisciplinary sub-area of bioinorganic chemistry has received the growing attention of researchers in the search for promising antimicrobial, antimalarial, antiviral, and antitumor chemotherapeutic agents. An excellent compilat...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Ul-Islam, Shahid (Editor ), Hashmi, Athar Adil (Editor ), Khan, Salman Ahmad (Editor )
Formato: eBook
Idioma:Inglés
Publicado: Hoboken, NJ : Wiley-Scrivener, 2020.
Edición:First edition.
Temas:
Metals > Therapeutic use.
Métallothérapie.
Metals > Therapeutic use
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title Page
  • Copyright Page
  • Contents
  • Preface
  • Chapter 1 Metallodrugs in Medicine: Present, Past, and Future Prospects
  • 1.1 Introduction
  • 1.2 Therapeutic Metallodrugs
  • 1.2.1 Anticancer Metallodrugs
  • 1.2.1.1 Mechanism of Anticancer Action
  • 1.2.2 Antimicrobial and Antiviral Metallodrugs
  • 1.2.2.1 Antimicrobial Metallodrugs
  • 1.2.2.2 Antiviral Metallodrugs
  • 1.2.3 Radiopharmaceuticals and Radiodiagnostic Metallodrugs
  • 1.2.4 Anti-Diabetic Metallodrugs
  • 1.2.5 Catalytic Metallodrugs
  • 1.3 Future Prospects
  • 1.4 Conclusion
  • References
  • Chapter 2 Chemotherapeutic Potential of Ruthenium Metal Complexes Incorporating Schiff Bases
  • 2.1 Introduction
  • 2.2 Schiff Base Complexes of Ruthenium as Anticancer Agents
  • 2.3 Conclusion
  • References
  • Chapter 3 Role of Metallodrugs in Medicinal Inorganic Chemistry
  • 3.1 Introduction
  • 3.2 Platinum Anticancer Drugs
  • 3.2.1 Nucleophilic Displacement Reactions in Complexes of Platinum
  • 3.2.2 Mode of the Interaction of Cisplatin Species With Nitrogen Donors of DNA Strand
  • 3.2.3 Systemic Toxicity of Cisplatin
  • 3.3 Copper-Based Anticancer Complexes
  • 3.3.1 Copper is Essential for Health and Nutrition
  • 3.3.2 Healthcare Applications of Copper
  • 3.3.3 Copper and Human Health Disorders
  • 3.3.3.1 Wilson's Disease (WD)
  • 3.3.3.2 Menkes' Disease
  • 3.3.4 Role of Copper Complexes as Potential Therapeutic Agents
  • 3.3.4.1 Thiosemicarbazones-Based Complexes
  • 3.3.4.2 Quinolones-Based Copper Complexes
  • 3.3.4.3 Naphthoquinones
  • 3.4 Zinc Anticancer Complexes
  • 3.4.1 Biologically Importance of Zinc
  • 3.4.2 Schiff Base Chemistry
  • 3.4.2.1 Schiff Base and Their Metal Complexes
  • 3.4.3 Zinc-Based Complexes
  • 3.4.4 Top Food Sources of Zinc
  • 3.4.5 Role of Zinc in Human Body
  • 3.4.6 Zinc as a Health Benefit
  • 3.4.7 Zinc in Alloy and Composites
  • 3.4.8 Zinc Supplementation as a Treatment
  • 3.4.8.1 Zinc Deficiency
  • 3.4.8.2 Zinc Toxicity
  • 3.4.8.3 Zinc and Viral Infections
  • 3.4.9 Gastrointestinal Effects
  • 3.5 Future Prospects of Metallodrugs
  • References
  • Chapter 4 Ferrocene-Based Metallodrugs
  • 4.1 Introduction
  • 4.2 Ferrocene-Based Antimalarial Agents
  • 4.2.1 Mechanism of Action
  • 4.3 Ferrocene-Based Antibacterial and Antifungal Drugs
  • 4.3.1 Schiff Base Derived Ferrocene Conjugates as Antibacterial Agents
  • 4.3.2 Ferrocenyl Guanidines as Antibacterial and Antifungal Agents
  • 4.3.3 Sedaxicene as Antifungal Agents
  • 4.4 Ferrocene-Based Anti-Tumor and Anti-Cancerous Drugs
  • 4.4.1 Ferricenium Salts as Anti-Tumor Agents
  • 4.4.2 Ferrocenylalkylazoles Active Anti-Tumor Drugs
  • 4.4.3 Ferrocene Conjugated to Peptides for Lung Cancer
  • 4.4.4 Ferrocenylalkyl Nucleobases Potential Anti-Cancerous Drugs
  • 4.4.5 Ferrocenyl Sub-Ordinates of Illudin-M
  • 4.4.6 Ferrocenyl Derivatives of Retinoids Potential Anti-Tumor Drug

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