Bioadhesives in drug delivery

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Mittal, K. L., 1945- (Editor )
Formato: eBook
Idioma:Inglés
Publicado: Hoboken, NJ : Wiley-Scrivener, 2020.
Edición:First edition.
Colección:Adhesion and Adhesives: Fundamental and Applied Aspects Ser.
Temas:
Bioadhesive drug delivery systems.
Systèmes bioadhésifs (Administration des médicaments)
Bioadhesive drug delivery systems
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title Page
  • Copyright Page
  • Contents
  • Preface
  • Part 1 Fundamental Aspects
  • Chapter 1 Introduction, Theories and Mechanisms of Bioadhesion
  • 1.1 Introduction
  • 1.1.1 Historical Perspective
  • 1.1.2 Bioadhesion in Biological Systems
  • 1.1.3 Bioadhesive/Mucoadhesive
  • 1.1.4 Factors Affecting Mucoadhesion
  • 1.1.4.1 Molecular Weight of Polymer
  • 1.1.4.2 Concentration of Polymer Used
  • 1.1.4.3 Flexibility of Polymer Chains
  • 1.1.4.4 Swelling
  • 1.1.4.5 pH at Polymer-Mucus Interface
  • 1.1.4.6 Mucin Turnover Rate
  • 1.1.4.7 Stereochemistry
  • 1.2 Bioadhesive Interactions
  • 1.3 The Mechanistic Approach to Bioadhesion
  • 1.4 Factors Controlling Bioadhesion
  • 1.4.1 Chemical Interactions
  • 1.4.1.1 Mussel Adhesion
  • 1.4.1.2 Cell Adhesion to Biomaterials
  • 1.4.2 Surface Morphology Effects
  • 1.4.3 Physiological Factors
  • 1.4.4 Physical and Mechanical Factors
  • 1.4.4.1 Wetting Phenomenon
  • 1.4.4.2 Interpenetration
  • 1.5 Theories of Bioadhesion
  • 1.5.1 Wetting Theory
  • 1.5.2 Diffusion Theory
  • 1.5.3 Electronic Theory
  • 1.5.4 Adsorption Theory
  • 1.5.5 Fracture Theory
  • 1.6 Stages of Mucoadhesion
  • 1.7 Modulation of Mucoadhesion
  • 1.8 Adhesion Promoters
  • 1.9 Surface Free Energy Analysis of Bioadhesion
  • 1.10 Molecular Biology in Bioadhesion
  • 1.11 Bioadhesives from Marine Sources
  • 1.12 Mucoadhesive Drug Delivery Systems
  • 1.13 Summary
  • References
  • Chapter 2 Bioadhesive Polymers for Drug Delivery Applications
  • 2.1 Introduction
  • 2.1.1 Drug Delivery
  • 2.2 Bioadhesive/Mucoadhesive Drug Delivery Systems
  • 2.2.1 Some Advantages of the Bioadhesive/Mucoadhesive Drug Delivery Systems
  • 2.2.2 The General Need for Bioadhesive/Mucoadhesive Drug Delivery Systems
  • 2.3 Mechanism of Bioadhesion
  • 2.4 Requirements for an Ideal Bioadhesive/ Mucoadhesive Polymer
  • 2.5 Factors Affecting Bioadhesion/Mucoadhesion
  • 2.5.1 Polymer Related Factors
  • 2.5.1.1 Molecular Weight
  • 2.5.1.2 Chain Length
  • 2.5.1.3 Flexibility
  • 2.5.1.4 Cross-Linking
  • 2.5.1.5 Presence of Functional Groups
  • 2.5.1.6 Concentration of Active Polymer
  • 2.5.2 Environmental Factors
  • 2.5.2.1 pH and Charge on the Polymer
  • 2.5.2.2 Degree of Hydration
  • 2.5.2.3 Initial Contact Time
  • 2.5.2.4 Applied Pressure
  • 2.5.2.5 Swelling
  • 2.5.2.6 Ionic Strength
  • 2.5.2.7 Mucus Gel Viscosity
  • 2.5.3 Physiological Factors
  • 2.5.3.1 Mucin Turnover
  • 2.5.3.2 Disease States
  • 2.6 Bioadhesive Polymers for Drug Delivery Applications
  • 2.6.1 Polymers
  • 2.6.1.1 Natural Polymers
  • 2.6.1.2 Synthetic Polymers
  • 2.6.2 Bioadhesive/Mucoadhesive Polymers
  • 2.6.3 Classification of Mucoadhesive Polymers
  • 2.6.3.1 Classification Based on the Origin of the Polymer
  • 2.6.3.2 Classification Based on Aqueous Solubility of the Polymer
  • 2.6.3.3 Classification Based on the Type of Charge on the Polymer
  • 2.6.4 Natural Polymers
  • 2.6.4.1 Chitosan
  • 2.6.4.2 Starch
  • 2.6.4.3 Gelatin
  • 2.6.4.4 Alginates

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