Fundamentals of analytical toxicology

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Flanagan, Robert J.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: [Place of publication not identified] : John Wiley, 2016.
Edición:2nd edition.
Temas:
Analytical toxicology.
Toxicologie analytique.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title Page
  • Copyright
  • Contents
  • Preface
  • Health and Safety
  • Nomenclature, Symbols, and Conventions
  • Uniform Resource Locators
  • Amount Concentration and Mass Concentration
  • Acknowledgements
  • List of Abbreviations
  • Section A The Basics
  • Chapter 1 Analytical Toxicology: Overview
  • 1.1 Introduction
  • 1.2 Modern analytical toxicology
  • 1.2.1 Analytical methods
  • 1.2.2 Systematic toxicological analysis
  • 1.2.3 Ethanol and other volatile substances
  • 1.2.4 Trace elements and toxic metals
  • 1.3 Provision of analytical toxicology services
  • 1.3.1 Samples and sampling
  • 1.3.2 Choice of analytical method
  • 1.3.3 Method validation and implementation
  • 1.3.4 Quality control and quality assessment
  • 1.4 Applications of analytical toxicology
  • 1.4.1 Clinical toxicology
  • 1.4.2 Forensic toxicology
  • 1.4.3 Testing for substance misuse
  • 1.4.4 Therapeutic drug monitoring
  • 1.4.5 Occupational and environmental toxicology
  • 1.5 Summary
  • References
  • Chapter 2 Sample Collection, Transport, and Storage
  • 2.1 Introduction
  • 2.2 Clinical samples and sampling
  • 2.2.1 Health and safety
  • 2.2.2 Clinical sample types
  • 2.2.3 Blood and blood fractions
  • 2.2.3.1 Arterial blood
  • 2.2.3.2 Venous blood
  • 2.2.3.3 Serum
  • 2.2.3.4 Plasma
  • 2.2.3.5 Blood cells
  • 2.2.3.6 Dried blood spots
  • 2.2.3.7 Volumetric microsampling
  • 2.2.4 Urine
  • 2.2.5 Stomach contents
  • 2.2.6 Faeces
  • 2.2.7 Tissues
  • 2.3 Guidelines for sample collection for analytical toxicology
  • 2.3.1 Sample collection and preservation
  • 2.3.2 Blood
  • 2.3.2.1 Collection of blood post-mortem
  • 2.3.3 Urine
  • 2.3.4 Stomach contents
  • 2.3.5 Oral fluid
  • 2.3.6 Sweat
  • 2.3.7 Exhaled air
  • 2.3.8 Cerebrospinal fluid
  • 2.3.9 Vitreous humour
  • 2.3.10 Synovial fluid
  • 2.3.11 Pericardial fluid
  • 2.3.12 Intraosseous fluid
  • 2.3.13 Liver
  • 2.3.14 Bile
  • 2.3.15 Other tissues
  • 2.3.16 Insect larvae
  • 2.3.17 Keratinaceous tissues (hair and nail)
  • 2.3.18 Bone
  • 2.3.19 Injection sites
  • 2.3.20 Scene residues
  • 2.4 Sample transport, storage, and disposal
  • 2.5 Common interferences
  • 2.6 Summary
  • References
  • Chapter 3 Basic Laboratory Operations
  • 3.1 Introduction
  • 3.1.1 Reagents and standard solutions
  • 3.1.2 Reference compounds
  • 3.1.3 Preparation and storage of calibration solutions
  • 3.2 Aspects of quantitative analysis
  • 3.2.1 Analytical error
  • 3.2.2 Minimizing random errors
  • 3.2.2.1 Preparation of a solution of known concentration
  • 3.2.3 Accuracy and precision
  • 3.2.3.1 Assessing precision and accuracy
  • 3.2.3.2 Detecting systematic error (fixed bias)
  • 3.2.3.3 Identifying sources of variation: analysis of variance
  • 3.2.3.4 Measurement uncertainty
  • 3.2.4 Calibration graphs
  • 3.2.4.1 Linear regression
  • 3.2.4.2 Testing for linearity
  • 3.2.4.3 Weighted linear regression
  • 3.2.4.4 Non-linear calibration
  • 3.2.4.5 Residuals and standardized residuals

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