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Structural biology in drug discovery : methods, techniques, and practices /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, NJ :
Wiley,
2019.
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| Edición: | First edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- <P>List of Contributors</p> <p>Preface</p> <p>Chapter 01: The Evolving Role of Structural Biology in Drug Discovery</p> <p>Chapter 02: A Structural View on Druggability: Experimental and Computational Approaches</p> <p>Chapter 03: Structural Chemogenomics: Profiling Protein-Ligand Interactions in Polypharmacological Space</p> <p>Chapter 04: Fragment-Based Ligand Discovery</p> <p>Chapter 05: Combining Structural, Thermodynamic and Kinetic Information to Drive Hit-to-Lead Progression</p> <p>Chapter 06: Allostery as Structure-Encoded Collective Dynamics: Significance in Drug Design</p> <p>Chapter 07: Biophysical Assessment of Target Protein Quality in Structure-Based Drug discovery</p> <p>Chapter 08: An Industrial Perspective on Protein-Ligand Complex Crystallization</p> <p>Chapter 09: Membrane Protein Crystallization</p> <p>Chapter 10: High-throughput Macromolecular Crystallography in Drug Discovery: Evolving in the Midst of Revolutions</p> <p>Chapter 11: Assessment of Crystallographic Structure Quality and Protein
- Ligand Complex Structure Validation</p> <p>Chapter 12: Complementary Information from Neutron Crystallography Studies</p> <p>Chapter 13: Determination of Protein Structure and Dynamics by NMR: State of the Art and Application to the Characterization of Biotherapeutics</p> <p>Chapter 14: NMR Studies of Protein
- Small Molecule Interactions for Drug Discovery</p> <p>Chapter 15: Computational Structural Biology for Drug Discovery: Power and Limitations</p> <p>Chapter 16: The Role of Structural Biology in Kinase Inhibitors Drug Discovery Success</p> <p>Chapter 17: Serine Proteinases from the Blood Coagulation Cascade</p> <p>Chapter 18: Epigenetic Proteins as Emerging Drug Targets</p> <p>Chapter 19: Impact of Recently Determined Crystallographic Structures of GPCRs on Drug Discovery</p> <p>Chapter 20: Targeting Protein-Protein Interactions Perspective</p> <p>Chapter 21: Mass Spectrometry-Based Strategies for Therapeutic Antibodies Extensive Characterization and Optimization (OptimAbs)</p> <p>Chapter 22: Integrating Evolution of Drug Resistance into Drug Discovery: Lessons from the Viral Proteases of HIV-1 and HCV</p> <p>Chapter 23: A Comprehensive Review on Mycobacterium Tuberculosis Targets and Drug Development from a Structural Perspective</p> <p>Chapter 24: Using Crystal Structures of Drug-Metabolizing Enzymes in Mechanism-Based Modeling for Drug Design</p> <p>Chapter 25: Intrinsically Disordered Proteins (IDPs): Targets for the Future?</p> <p>Chapter 26: Cryo-electron Microscopy as a Tool for Drug Discovery in the Context of Integrative Structural Biology</p> <p>Chapter 27: Application of Hard-X-ray Free-electron Lasers for Static and Dynamic Processes in Structural Biology</p>