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|a UAMI
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| 245 |
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|a Structural biology in drug discovery :
|b methods, techniques, and practices /
|c edited by Jean-Paul Renaud.
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| 250 |
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|a First edition.
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| 264 |
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1 |
|a Hoboken, NJ :
|b Wiley,
|c 2019.
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| 300 |
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|a 1 online resource
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| 336 |
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|a <P>List of Contributors</p> <p>Preface</p> <p>Chapter 01: The Evolving Role of Structural Biology in Drug Discovery</p> <p>Chapter 02: A Structural View on Druggability: Experimental and Computational Approaches</p> <p>Chapter 03: Structural Chemogenomics: Profiling Protein-Ligand Interactions in Polypharmacological Space</p> <p>Chapter 04: Fragment-Based Ligand Discovery</p> <p>Chapter 05: Combining Structural, Thermodynamic and Kinetic Information to Drive Hit-to-Lead Progression</p> <p>Chapter 06: Allostery as Structure-Encoded Collective Dynamics: Significance in Drug Design</p> <p>Chapter 07: Biophysical Assessment of Target Protein Quality in Structure-Based Drug discovery</p> <p>Chapter 08: An Industrial Perspective on Protein-Ligand Complex Crystallization</p> <p>Chapter 09: Membrane Protein Crystallization</p> <p>Chapter 10: High-throughput Macromolecular Crystallography in Drug Discovery: Evolving in the Midst of Revolutions</p> <p>Chapter 11: Assessment of Crystallographic Structure Quality and Protein -- Ligand Complex Structure Validation</p> <p>Chapter 12: Complementary Information from Neutron Crystallography Studies</p> <p>Chapter 13: Determination of Protein Structure and Dynamics by NMR: State of the Art and Application to the Characterization of Biotherapeutics</p> <p>Chapter 14: NMR Studies of Protein -- Small Molecule Interactions for Drug Discovery</p> <p>Chapter 15: Computational Structural Biology for Drug Discovery: Power and Limitations</p> <p>Chapter 16: The Role of Structural Biology in Kinase Inhibitors Drug Discovery Success</p> <p>Chapter 17: Serine Proteinases from the Blood Coagulation Cascade</p> <p>Chapter 18: Epigenetic Proteins as Emerging Drug Targets</p> <p>Chapter 19: Impact of Recently Determined Crystallographic Structures of GPCRs on Drug Discovery</p> <p>Chapter 20: Targeting Protein-Protein Interactions Perspective</p> <p>Chapter 21: Mass Spectrometry-Based Strategies for Therapeutic Antibodies Extensive Characterization and Optimization (OptimAbs)</p> <p>Chapter 22: Integrating Evolution of Drug Resistance into Drug Discovery: Lessons from the Viral Proteases of HIV-1 and HCV</p> <p>Chapter 23: A Comprehensive Review on Mycobacterium Tuberculosis Targets and Drug Development from a Structural Perspective</p> <p>Chapter 24: Using Crystal Structures of Drug-Metabolizing Enzymes in Mechanism-Based Modeling for Drug Design</p> <p>Chapter 25: Intrinsically Disordered Proteins (IDPs): Targets for the Future?</p> <p>Chapter 26: Cryo-electron Microscopy as a Tool for Drug Discovery in the Context of Integrative Structural Biology</p> <p>Chapter 27: Application of Hard-X-ray Free-electron Lasers for Static and Dynamic Processes in Structural Biology</p>
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 650 |
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|a Drug development.
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| 650 |
|
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|a Molecular biology.
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| 650 |
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2 |
|a Molecular Biology
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| 650 |
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6 |
|a Médicaments
|x Développement.
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| 650 |
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6 |
|a Biologie moléculaire.
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| 650 |
|
7 |
|a molecular biology.
|2 aat
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| 650 |
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|a Drug development
|2 fast
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| 650 |
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7 |
|a Molecular biology
|2 fast
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| 700 |
1 |
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|a Renaud, Jean-Paul,
|d 1960-
|e editor.
|1 https://id.oclc.org/worldcat/entity/E39PCjKWWtCXtTWKvj7XVvMybd
|
| 758 |
|
|
|i has work:
|a Structural biology in drug discovery (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGRkJTTdcxQ7WWVxPWkwbq
|4 https://id.oclc.org/worldcat/ontology/hasWork
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0 |
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|i Print version:
|t Structural biology in drug discovery.
|b First edition.
|d Hoboken, NJ : Wiley, 2019
|w (DLC) 2019015619
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=6011633
|z Texto completo
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