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|a (OCoLC)1121125762
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|a UAMI
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1 |
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|a Provan, Drew.
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| 245 |
1 |
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|a Molecular Hematology
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| 250 |
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|a 4th ed.
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| 260 |
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|a Newark :
|b John Wiley & Sons, Incorporated,
|c 2019.
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| 300 |
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|a 1 online resource (420 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Print version record.
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|a 2 Stem cellsIntroduction; Stem cell definitions and distinctions; Hematopoietic stem cell concepts and their origin; The cellular compartment model; Models of lineage commitment; Molecular regulation of hematopoiesis; Cell-intrinsic regulators of hematopoiesis; Cell-extrinsic regulators; Components of the hematopoietic microenvironmental niche; Trafficking of primitive hematopoietic cells; Hematopoietic ontogeny; Homing and engraftment of HSCs following infusion; Egress of HSCs from bone marrow under physiological conditions; Manipulating HSCs for clinical use; Mobilization of HSCs
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| 505 |
8 |
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|a Isolating stem cells for manipulationSummary; Further reading; 3 The genetics of acute myeloid leukemias; Introduction; AML with recurrent cytogenetic abnormalities; Core-binding factor leukemias; Acute promyelocytic leukemia; KMT2A gene rearrangements (11q23); Other rare chromosomal translocations; Numerical chromosomal abnormalities; Molecular genetic aberrations not detectable by conventional cytogenetics; Driver gene mutations; Activated signaling; Myeloid transcription factors; Tumor suppressors; Spliceosome genes; Cohesin complex genes; DNA methylation; Chromatin modifiers
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| 505 |
8 |
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|a AML therapies and MRD monitoring targeted by geneticsSummary; Further reading; 4 Molecular diagnostics and risk assessment in myeloid malignancies; Introduction; Clonal hematopoiesis; Myelodysplastic syndromes; Acute myeloid leukemia; General methodology of cytogenetic analysis in hematological malignancies; Methods of detection; Genetic and clinical consequences of chromosomal translocation; Karyotypic evolution; Clinical implications; Treatment selection; Recurrent cytogenetic abnormalities in MDS; Recurrent cytogenetic aberrations in AML
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| 500 |
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|a Therapy-related chromosomal aberrations in secondary AML
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 650 |
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0 |
|a Blood
|x Diseases
|x Molecular aspects.
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| 650 |
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6 |
|a Sang
|x Maladies
|x Aspect moléculaire.
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| 650 |
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7 |
|a Blood
|x Diseases
|x Molecular aspects
|2 fast
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| 700 |
1 |
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|a Gribben, John.
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| 758 |
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|i has work:
|a Molecular hematology (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCFPdxy4R4v4wqwTC4QvpGd
|4 https://id.oclc.org/worldcat/ontology/hasWork
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| 776 |
0 |
8 |
|i Print version:
|a Provan, Drew.
|t Molecular Hematology.
|d Newark : John Wiley & Sons, Incorporated, ©2019
|z 9781119252870
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| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=5904671
|z Texto completo
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| 880 |
0 |
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|6 505-00/(S
|a Intro; Molecular Hematology; Dedication; Contents; Contributors; Preface to the fourth edition; Further reading; Acknowledgments; 1 Beginnings: the molecular pathology of hemoglobin; Historical background; The structure, genetic control, and synthesis of normal hemoglobin; Structure and function; Genetic control of hemoglobin; Gene action and globin synthesis; Regulation of hemoglobin synthesis; Regulation of developmental changes in globin gene expression; The molecular pathology of hemoglobin; The β thalassemias; Defective β globin gene transcription
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| 880 |
8 |
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|6 505-00/(S
|a Mutations that cause abnormal processing of mRNAMutations that result in abnormal translation of β globin mRNA; Unstable β globin chain variants; The α thalassemias; Rarer forms of thalassemia and related disorders; Genotype-phenotype relationships in the thalassemias; The β thalassemias; Phenotypic diversity; The α thalassemias; Structural hemoglobin variants; Molecular pathology; Genotype-phenotype relationships; Molecular aspects of the high frequency of the hemoglobin variants; Molecular aspects of the prevention and management of the hemoglobin disorders; Postscript; Further reading
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| 938 |
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|a ProQuest Ebook Central
|b EBLB
|n EBL5904671
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|a 92
|b IZTAP
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