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Quantitative pharmacology and individualized therapy strategies in development of therapeutic proteins for immune-mediated inflammatory diseases /
"Focused on quantitative pharmacology and individualized therapy for developing biotherapeutics in immune-mediated inflammatory diseases, this book discusses both theoretical and practical aspects and includes case studies illustrating applications in drug development. Provides frontline knowle...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, NJ :
Wiley,
2019.
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| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Disease Interception in Autoimmune Diseases: From a Conceptual Framework to Practical Implementation / Anish Suri
- The Role of Biomarkers in Treatment Algorithms for Ulcerative Colitis (UC) / Reena Khanna, Brian G Feagan
- Mechanism and Physiologically Based PK/PD Model in Assisting Translation from Preclinical to Clinical: Understanding PK/PD of Therapeutic Proteins at Site-of-Action / Xi Chen, Weirong Wang
- Application of Minimal Anticipated Biological Effect Level (MABEL) in Human Starting Dose Selection for Immunomodulatory Protein Therapeutics
- Principles and Case Studies / Haiqing Wang, Zheng Yang, Rong Shi
- Model-Based Meta-Analysis Use in the Development of Therapeutic Proteins / Timothy J Taylor, Bill Frame, Angela D Taylor
- Utility of Joint Population Exposure-Response Modeling Approach to Assess Multiple Continuous and Categorical Endpoints in Immunology Drug Development / Chuanpu Hu, Honghui Zhou
- Modeling Approaches to Characterize Target-Mediated Pharmacokinetics and Pharmacodynamics for Therapeutic Proteins / Leonid Gibiansky, Ekaterina Gibiansky
- Tutorial: Numerical (NONMEM) Implementation of the Target-Mediated Drug Disposition Model / Leonid Gibiansky, Ekaterina Gibiansky
- Translational Considerations in Developing Bispecific Antibodies: What Can We Learn from Quantitative Pharmacology? / Pradeep B Lukka, Santosh Wagh, Bernd Meibohm
- Application of Pharmacometrics and Systems Pharmacology to Current and Emerging Biologics in Inflammatory Bowel Diseases / Sihem Ait-Oudhia, Yi Ting (Kayla) Lien, Sumit Basu, Lawrence Lesko, Stephan Schmidt
- Pharmacokinetics-Based Dosing for Therapeutic Monoclonal Antibodies in Inflammatory Bowel Disease / Niels Vande Casteele, William J Sandborn
- Pharmacokinetics-Based Dosing Strategies for Therapeutic Proteins in Inflammatory Bowel Disease / Diane R Mould, Richard N Upton, Jessica Wojciechowski
- Quantitative Pharmacology Approach to Select Optimal Dose and Study the Important Factors in Determining Disposition of Therapeutic Monoclonal Antibody in Pediatric Subjects
- Some Considerations / Deni Hardiansyah, Chee M Ng
- Quantitative Pharmacology Assessment Strategy Therapeutic Proteins in Pediatric Subjects
- Challenges and Opportunities / Jeremiah D Momper, Andrew Mulberg, Nitin Mehrotra, Dan Turner, William Faubion, Laurie Conklin, Karim Azer, Marla C Dubinsky
- Case Examples of Using Quantitative Pharmacology in Developing Therapeutic Proteins for Plaque Psoriasis
- Guselkumab / Zhenling Yao, Yaowei Zhu, Chuanpu Hu, Yang Chen, Shu Li, Bruce Randazzo, Zhenhua Xu, Amarnath Sharma, Honghui Zhou
- Vedolizumab-A Case Example of Using Quantitative Pharmacology in Developing Therapeutic Biologics in Inflammatory Bowel Disease / Maria Rosario, Nathanael L Dirks, Diane R Mould, Catherine Scholz, Timothy Wyant, Asit Parikh, Irving Fox
- Case Examples of Using Quantitative Pharmacology in Developing Therapeutic Proteins in Systemic Lupus Erythematosus
- Belimumab / Herbert Struemper
- Case Examples of Using Quantitative Pharmacology in Developing Therapeutic Proteins in Multiple Sclerosis
- Peginterferon Beta-1a, Daclizumab Beta, Natalizumab / Xiao Hu, Yaming Hang, Lei Diao, Kumar K Muralidharan, Ivan Nestorov
- Index
- Supplemental Images.