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The History of Alternative Test Methods in Toxicology.
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Elsevier Science & Technology,
2018.
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| Colección: | History of Toxicology and Environmental Health Ser.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; The History of Alternative Test Methods in Toxicology; The History of Alternative Test Methods in Toxicology; Copyright; Contents; Contributors; Biographical Notes; CO-EDITORS; CO-AUTHORS; Preface to the Series; Preface for The History of Alternative Test Methods in Toxicology; 1
- Setting the Scene; 1.1
- The Introduction and Influence of the Concept of Humane Experimental Technique; 1. INHUMANITY AND THE THREE RS CONCEPT; 2. PROGRESS FOLLOWING THE PUBLICATION OF THE PRINCIPLES; 3. ALTERNATIVES; 4. PROGRESS IN THE 1980S; 5. INTO THE 1990S; REFERENCES.
- 1.2
- Types of Toxicity and Applications of Toxicity Testing1. THE NEED FOR TESTING; 2. TYPES OF TOXICITY TEST; 3. APPLICATIONS OF TOXICITY TESTING; 4. RISK MANAGEMENT; 5. THE REPLACEMENT OF ANIMAL TESTS; 6. CONCLUSIONS; REFERENCES; 1.3
- The Key Technologies; 1. INTRODUCTION; 2. TECHNOLOGY DRIVERS; 2.1 Tissue Culture Systems; 2.2 Reporter Gene Assays and Biosensors; 2.3 Miniaturised and Large-Scale Culture Systems; 2.4 Toxicogenomics and Proteomics; 2.5 Other Enabling Technologies; 3. DISCUSSION AND CONCLUSIONS; REFERENCES; 2
- Contributions From Countries, Regions and Organisations.
- 2.1
- Alternative Methods in Toxicity Testing in the UK1. EARLY DAYS; 2. THE FUND FOR THE REPLACEMENT OF ANIMALS IN MEDICAL EXPERIMENTS; 3. THE NATIONAL CENTRE FOR THE THREE RS; 4. OTHER ORGANISATIONS; REFERENCES; 2.2
- Contributions From the German-Speaking Countries; 1. INTRODUCTION; 2. CONTRIBUTIONS FROM SWITZERLAND; 2.1 The Foundation Research 3R; 2.2 The Swiss Institute for Alternatives to Animal Testing; 2.3 The Fondation Egon Naef Pour la Recherche In Vitro; 2.4 Swiss Governmental Agency Support for the Three Rs Concept; 3. CONTRIBUTIONS FROM GERMANY.
- 3.1 Zentralstelle zur Erfassung und Bewertung von Ersatz- und Ergaenzungsmethoden zum Tierversuch (ZEBET)3.2 Reducing Animal Numbers in Regulatory Toxicity Testing; 3.3 The Regulatory Acceptance of In Vitro Toxicity Tests Successfully Validated at ZEBET; 3.4 The Funding of Research on In Vitro Toxicity Testing in Germany; 3.5 ZEBET's Wider Activities; 4. CONTRIBUTIONS FROM AUSTRIA; 5. CONCLUSIONS; REFERENCES; 2.3
- Contributions to Alternatives From Italy and Spain; 1. ACTIVITIES IN ITALY RELATED TO ALTERNATIVE METHODS; 1.1 The Italian Association for In Vitro Toxicology.
- 1.2 The Italian National Platform for Alternative Methods1.3 The Italian National Reference Centre; 1.4 The Three Rs Declaration of Bologna; 2. ACTIVITIES IN SPAIN RELATED TO IN VITRO PHARMACOTOXICOLOGY; 2.1 The ICLAS/CSIC Working Group on Complementary Methods; 2.2 The Spanish Working Group on Alternative Methods; 2.3 The 3ERRES Mailing List on Alternatives; 2.4 Spanish Scientific Productivity Related to In Vivo and In Vitro Alternative Methods; 2.5 The Inventory of the Spanish Institutions and Scientists Involved in Alternatives to the Use of Laboratory Animals.