Catalytic Processes for API Synthesis : From Laboratory to Industry.

Detalles Bibliográficos
Autor principal: Burke, Anthony J.
Otros Autores: Silva Marques, Carolina, Turner, Nicholas, Hermann, Gesine
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Newark : John Wiley & Sons, Incorporated, 2018.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover; Title Page; Copyright; Contents; Foreword; Preface; Abbreviations; Chapter 1 Catalysis and Prerequisites for the Modern Pharmaceutical Industry Landscape; 1.1 Introduction; 1.2 Key Historical Moments in Catalysis Development; 1.3 Key Historical Developments in Catalysis for API Synthesis: Including Catalytic Asymmetric Synthesis; 1.4 Catalytic Synthesis of APIs in the Twenty-First Century: New Developments, Paradigm Shifts, and Future Challenges; 1.5 Conclusions; References; Chapter 2 Catalytic Process Design: The Industrial Perspective; 2.1 Introduction; 2.2 Process Design.
  • 2.2.1 Heterogeneous and Homogeneous Catalysts2.2.2 Product Safety and Regulatory Requirements; 2.2.3 Control of Residual Metals; 2.2.3.1 Filtration and Adsorption; 2.2.3.2 Extraction and Scavenging; 2.2.3.3 Organic Solvent Nanofiltration (OSN); 2.2.4 Design of Experiment (DoE); 2.2.5 Catalyst Recycling; 2.2.6 Scalability, Safety, and Environmental Aspects; 2.3 Examples of Homogeneous and Heterogeneous Catalytic Reactions in API Manufacture; 2.3.1 Batch Operations; 2.3.2 Continuous-Flow Operations; 2.4 Conclusions; References; Chapter 3 Hydrogenation, Hydroformylation, and Other Reductions.
  • 3.1 Introduction3.2 Hydrogenation; 3.2.1 Hydrogenation of Alkenes; 3.2.1.1 Enamides; 3.2.2 Hydrogenation of Carbonyl Groups; 3.2.3 Hydrogenation of Imines; 3.3 Transfer Hydrogenation; 3.3.1 On Ketones; 3.3.2 On Imines; 3.4 Reductions with Oxazaborolidine Catalytic Systems; 3.5 Hydroformylation; 3.6 Reductions with Organocatalysts; 3.7 Other Catalytic Reductions; 3.7.1 Reduction of Nitro Units; 3.7.2 Other Reductions; 3.8 Conclusions; References; Chapter 4 Oxidation: Nobel Prize Chemistry Catalysis; 4.1 Introduction; 4.2 Olefin Epoxidation; 4.2.1 Metal-based Electrophilic Methods.
  • 4.2.1.1 The Sharpless-Katsuki Asymmetric Epoxidation4.2.1.2 The Jacobsen-Katsuki Asymmetric Epo; 4.2.2 Nucleophilic Methods; 4.2.2.1 Nucleophilic Methods with Hydrogen Peroxide; 4.2.3 Organocatalytic Methods; 4.3 Olefin Dihydroxylation; 4.4 Olefin Aminohydroxylation; 4.5 Sulfur Oxidation; 4.5.1 Synthesis of Sulfoxides
  • Use of Titanium, Molybdenum, and Vanadium Catalysts; 4.5.2 Synthesis of Sulfones
  • Use of Tungsten Catalysts; 4.6 Catalytic Oxidation of Carbonyls
  • Cu/Nitroxyl and Nitroxyl/NOx Catalytic Systems; 4.7 Oxidative Dehydrogenations (ODs); 4.8 Conclusions; References.
  • Chapter 5 Catalytic Addition Reactions5.1 Introduction; 5.2 1,2-Additions; 5.3 1,4-Additions; 5.4 Conclusions; References; Chapter 6 Catalytic Cross-Coupling Reactions
  • Nobel Prize Catalysis; 6.1 Introduction; 6.2 Heck-Mizoroki Reaction; 6.3 The Suzuki-Miyaura Reaction; 6.4 The Buchwald-Hartwig Reaction; 6.5 The Sonogashira-Hagihara Reaction; 6.6 The Allylic Substitution Reaction; 6.7 C-H Activation Processes; 6.8 Oxidative CC Bond Formation; 6.9 Conclusions; References; Chapter 7 Catalytic Metathesis Reactions: Nobel Prize Catalysis; 7.1 Introduction; 7.2 Metathesis with Ru-Based Catalysts.

Ejemplares similares