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Efficiency in natural product total synthesis /
Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. This book : Focuses on ef...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, NJ :
Wiley,
2018.
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| Edición: | First edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000 i 4500 | ||
|---|---|---|---|
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| 003 | OCoLC | ||
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| 008 | 180515s2018 nju ob 001 0 eng | ||
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| 020 | |a 1118940210 | ||
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| 049 | |a UAMI | ||
| 245 | 0 | 0 | |a Efficiency in natural product total synthesis / |c edited by Pei-Qiang Huang, Zhu-Jun Yao, Richard P. Hsung. |
| 250 | |a First edition. | ||
| 264 | 1 | |a Hoboken, NJ : |b Wiley, |c 2018. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record and CIP data provided by publisher. | |
| 505 | 8 | |a 1.2.4 The C-H Bond Functionalization Strategy1.2.5 The Building-Block Strategy; 1.2.6 The Collective Synthesis Strategy; 1.2.7 The Oligomerization Tactic; 1.3 The Expansion of the Field: Chemical Biology/Chemical Genetics; 1.3.1 Diversity-Oriented Synthesis (DOS); 1.3.2 Function-Oriented Synthesis (FOS); 1.3.3 Biology-Oriented Synthesis (BIOS); 1.3.4 Lead-Oriented Synthesis (LOS); 1.4 Addressing the Threats that Humans May Face in the Near Future; 1.4.1 A.G. Myers' Endeavor; 1.4.2 D.L. Boger's Endeavor; Acknowledgements; References. | |
| 505 | 0 | |a Intro; Title Page; Copyright Page; Contents; Contributors; Foreword; Preface; Introduction; 1 The Golden Age of the Total Synthesis of Natural Products: The Era as a Dominant Field; 2 1991-2000: A Contrasting Decade; 3 Total Synthesis in the Twenty-First Century; 4 The Challenges of the Efficiency in the Total Synthesis of Natural Products; 5 The Renaissance of Natural Products as Drug Candidates; 6 Recent Recognition of the Contribution of Natural Product-Based Drugs to Society; Acknowledgements; References; Chapter 1 Principles for Synthetic Efficiency and Expansion of the Field. | |
| 505 | 8 | |a 1.1 Concepts for Efficiency in the Total Synthesis of Natural Products1.1.1 Ideal Synthesis; 1.1.2 Selectivity; 1.1.3 Green Synthesis; 1.1.4 Atom Economy; 1.1.5 E Factors; 1.1.6 Step Economy; 1.1.7 Pot Economy and PASE (Pot, Atom, and Step Economy); 1.1.8 Redox Economy; 1.1.9 Protecting-Group-Free Synthesis; 1.1.10 Multicomponent Reactions and One-Pot Reactions; 1.1.11 Scalability; 1.1.12 Convergent Synthesis; 1.2 Biomimetic Synthesis; 1.2.1 Basic Logic of Biosynthesis; 1.2.2 Tandem, Cascade, and Domino Reactions -- One-Pot Reactions; 1.2.3 Site and Stereoselective Reactions. | |
| 505 | 8 | |a Chapter 2 Selected Procedure-Economical Enantioselective Total Syntheses of Natural Products2.1 One-Step/One-Pot Enantioselective Total Synthesis of Natural Products/Drugs; 2.1.1 Robinson's One-Step Synthesis of Tropinone; 2.1.2 Hayashi's One-Pot Synthesis of (+)-ABT-341; 2.2 Two-Step/Two-Pot Enantioselective Total Synthesis of Natural Products; 2.2.1 Hayashi's Two-Pot Synthesis of (−)-Oseltamivir; 2.2.2 Ma's Two-Pot Synthesis of (−)-Oseltamivir; 2.2.3 Li's Two-Step Chemoenzymatic Total Synthesis of Aszonalenin; 2.2.4 Ishikawa's Two-Step Total Syntheses of (+)-WIN 64821 and (+)-Naseseazine B | |
| 505 | 8 | |a 2.3 Three-Step/Three-Pot Enantioselective Total Synthesis of Natural Products2.3.1 Carreira's Three-Step Asymmetric Total Syntheses of (+)-Aszonalenin and (−)-Brevicompanine B; 2.3.2 Husson's Three-Step Asymmetric Total Synthesis of (−)-Sibirine; 2.3.3 MacMillan's Three-Step Asymmetric Total Synthesis of (+)-Frondosin B; 2.3.4 Hayashi's Three-Pot Total Synthesis of (−)-PGE1 Methyl Ester; 2.3.5 Porco's Three-Pot Total Synthesis of (−)-Hyperibone K; 2.4 Four-Step Enantioselective Total Synthesis of Natural Products; 2.4.1 Lawrence's Four-Step Total Synthesis of (−)-Angiopterlactone A | |
| 520 | |a Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. This book : Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science and describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Natural products |x Synthesis. | |
| 650 | 0 | |a Organic compounds |x Synthesis. | |
| 650 | 6 | |a Produits naturels |x Synthèse. | |
| 650 | 6 | |a Composés organiques |x Synthèse. | |
| 650 | 7 | |a SCIENCE |x Chemistry |x Organic. |2 bisacsh | |
| 650 | 7 | |a Natural products |x Synthesis |2 fast | |
| 650 | 7 | |a Organic compounds |x Synthesis |2 fast | |
| 700 | 1 | |a Huang, Peiqiang, |d 1962- |e editor. | |
| 700 | 1 | |a Yao, Zhu-Jun, |e editor. | |
| 700 | 1 | |a Hsung, Richard P., |e editor. | |
| 758 | |i has work: |a Efficiency in natural products total synthesis (Text) |1 https://id.oclc.org/worldcat/entity/E39PCFVtTgpfbVq8m38TrhGtjC |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |t Efficiency in natural product total synthesis. |b First edition. |d Hoboken, NJ : John Wiley & Sons, 2018 |z 9781118605400 |w (DLC) 2018008623 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=5472016 |z Texto completo |
| 938 | |a EBL - Ebook Library |b EBLB |n EBL5472016 | ||
| 938 | |a EBSCOhost |b EBSC |n 1855525 | ||
| 938 | |a YBP Library Services |b YANK |n 15610637 | ||
| 994 | |a 92 |b IZTAP | ||