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Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants.
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Newark :
John Wiley & Sons, Incorporated,
2018.
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| Edición: | 2nd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro; Volume 1; Title Page; Copyright Page; Contents; List of Contributors; Foreword; Part 1 Basic Concepts; Chapter 1 Contributions of Plasma Protein Binding and Membrane Transporters to Drug-Induced Mitochondrial Toxicity; 1.1 Drug Accumulation; 1.2 Small Molecule Delivery to Tissues; 1.3 Entry into Cells; 1.4 Transport Out of Cells; 1.5 Entry into Mitochondria; 1.6 Export from Mitochondria; 1.7 Concluding Remarks; References; Chapter 2 The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity; 2.1 Introduction to Chapter; 2.2 The Solute Carrier (SLC) Superfamily.
- 2.3 Transporters as Determinants of Drug Levels in Tissues and Subcellular Compartments2.4 Drug Transporters in the Intestine; 2.5 Drug Transporters in the Liver; 2.6 Drug Transporters in the Kidney; 2.6.1 Conservation Mechanisms; 2.6.2 Detoxification Mechanisms; 2.7 Mitochondrial Transporters; 2.8 Conclusions; References; Chapter 3 Structure-Activity Modeling of Mitochondrial Dysfunction; 3.1 Introduction; 3.1.1 Mitochondrial Structure and Function; 3.1.2 Mechanisms of Mitochondrial Toxicity; 3.2 Mitochondrial Toxicity Data Sources; 3.2.1 Zhang Dataset; 3.2.2 ToxCast Data.
- 3.3 In Silico Modeling of Mitochondrial Toxicity3.3.1 Statistical Modeling; 3.3.2 Structural Alert Modeling; 3.4 Mechanistic Chemistry Covered by the Existing Structural Alerts; 3.5 Structural Alert Applicability Domains: Physicochemical Properties; 3.6 Future Direction: Structure-Activity Studies for Other Mechanisms of Mitochondrial Toxicity; 3.7 Concluding Remarks; References; Chapter 4 Mitochondria-Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic-Induced Toxicity; 4.1 Introduction; 4.2 Multiplicity of Mitochondrial CYPs.
- 4.3 Targeting and Significance of Multiple Forms of Mitochondrial CYPs4.3.1 Mitochondrial Import of CYP1A1; 4.3.2 Mitochondrial Import of CYP1B1; 4.3.3 Mitochondrial Import of CYP2C8; 4.3.4 Mitochondrial Import of CYP2D6; 4.3.5 Mitochondrial Import of CYP2B1 and CYP2E1; 4.3.6 Import Mechanism of GSH-Conjugating GSTA4-4; 4.4 Variations in Mitochondrial CYPs and Drug Metabolism; 4.5 Physiological and Toxicological Significance of Mitochondria-Targeted CYPs; 4.6 Mitochondrial CYPs and Cell Signaling; 4.7 Conclusion; Acknowledgment; References; Part 2 Organ Drug Toxicity: Mitochondrial Etiology.