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180331s2018 nju o 000 0 eng d |
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|a EBLCP
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|a 9781119329732
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|a 1119329736
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|b 1018275967
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|a 615.9/02
|2 23
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|a UAMI
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|a Will, Yvonne.
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|a Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants.
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| 250 |
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|a 2nd ed.
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| 260 |
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|a Newark :
|b John Wiley & Sons, Incorporated,
|c 2018.
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| 300 |
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|a 1 online resource (812 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Print version record.
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|6 880-01
|a Intro; Volume 1; Title Page; Copyright Page; Contents; List of Contributors; Foreword; Part 1 Basic Concepts; Chapter 1 Contributions of Plasma Protein Binding and Membrane Transporters to Drug-Induced Mitochondrial Toxicity; 1.1 Drug Accumulation; 1.2 Small Molecule Delivery to Tissues; 1.3 Entry into Cells; 1.4 Transport Out of Cells; 1.5 Entry into Mitochondria; 1.6 Export from Mitochondria; 1.7 Concluding Remarks; References; Chapter 2 The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity; 2.1 Introduction to Chapter; 2.2 The Solute Carrier (SLC) Superfamily.
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|a 2.3 Transporters as Determinants of Drug Levels in Tissues and Subcellular Compartments2.4 Drug Transporters in the Intestine; 2.5 Drug Transporters in the Liver; 2.6 Drug Transporters in the Kidney; 2.6.1 Conservation Mechanisms; 2.6.2 Detoxification Mechanisms; 2.7 Mitochondrial Transporters; 2.8 Conclusions; References; Chapter 3 Structure-Activity Modeling of Mitochondrial Dysfunction; 3.1 Introduction; 3.1.1 Mitochondrial Structure and Function; 3.1.2 Mechanisms of Mitochondrial Toxicity; 3.2 Mitochondrial Toxicity Data Sources; 3.2.1 Zhang Dataset; 3.2.2 ToxCast Data.
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|a 3.3 In Silico Modeling of Mitochondrial Toxicity3.3.1 Statistical Modeling; 3.3.2 Structural Alert Modeling; 3.4 Mechanistic Chemistry Covered by the Existing Structural Alerts; 3.5 Structural Alert Applicability Domains: Physicochemical Properties; 3.6 Future Direction: Structure-Activity Studies for Other Mechanisms of Mitochondrial Toxicity; 3.7 Concluding Remarks; References; Chapter 4 Mitochondria-Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic-Induced Toxicity; 4.1 Introduction; 4.2 Multiplicity of Mitochondrial CYPs.
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| 505 |
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|a 4.3 Targeting and Significance of Multiple Forms of Mitochondrial CYPs4.3.1 Mitochondrial Import of CYP1A1; 4.3.2 Mitochondrial Import of CYP1B1; 4.3.3 Mitochondrial Import of CYP2C8; 4.3.4 Mitochondrial Import of CYP2D6; 4.3.5 Mitochondrial Import of CYP2B1 and CYP2E1; 4.3.6 Import Mechanism of GSH-Conjugating GSTA4-4; 4.4 Variations in Mitochondrial CYPs and Drug Metabolism; 4.5 Physiological and Toxicological Significance of Mitochondria-Targeted CYPs; 4.6 Mitochondrial CYPs and Cell Signaling; 4.7 Conclusion; Acknowledgment; References; Part 2 Organ Drug Toxicity: Mitochondrial Etiology.
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| 500 |
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|a 5.4.1 Acetaminophen.
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 650 |
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0 |
|a Drugs
|x Toxicology.
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| 650 |
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|a Mitochondrial pathology.
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| 650 |
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6 |
|a Médicaments
|x Toxicologie.
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| 650 |
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6 |
|a Maladies mitochondriales.
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| 650 |
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7 |
|a Drugs
|x Toxicology
|2 fast
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| 650 |
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7 |
|a Mitochondrial pathology
|2 fast
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| 700 |
1 |
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|a Dykens, James A.
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| 758 |
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|i has work:
|a Mitochondrial dysfunction caused by drug and environmental toxicants (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGWVH8cFcMCHy88HkwR4YP
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|a Will, Yvonne.
|t Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants.
|d Newark : John Wiley & Sons, Incorporated, ©2018
|z 9781119329701
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=5327221
|z Texto completo
|
| 880 |
8 |
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|6 505-01/(S
|a Chapter 5 Mitochondrial Dysfunction in Drug-Induced Liver Injury5.1 Introduction; 5.2 Structure and Physiological Role of Mitochondria; 5.2.1 Structure and Main Components of Mitochondria; 5.2.2 Oxidation of Pyruvate and Fatty Acids; 5.2.3 Production of ATP; 5.2.4 Production of ROS as Signaling Molecules; 5.3 Main Consequences of Hepatic Mitochondrial Dysfunction; 5.3.1 Consequences of Mitochondrial β-Oxidation Inhibition; 5.3.2 Consequences of MRC Inhibition; 5.3.3 Consequences of Mitochondrial Membrane Permeabilization; 5.4 Main Hepatotoxic Drugs Inducing Mitochondrial Dysfunction.
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| 938 |
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|a ProQuest Ebook Central
|b EBLB
|n EBL5327221
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| 994 |
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|a 92
|b IZTAP
|
