Privileged structures in drug discovery : medicinal chemistry and synthesis /

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a c...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Yet, Larry (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, NJ : Wiley, 2018.
Edición:Edition 1.
Temas:
Pharmaceutical chemistry.
Drug development > Methodology.
Molecular structure.
Drug Discovery > methods
Chemistry, Pharmaceutical > methods
Molecular Structure
Chemistry, Pharmaceutical
Chimie pharmaceutique.
Médicaments > Développement > Méthodologie.
Structure moléculaire.
molecular structure.
MEDICAL > Pharmacology.
Molecular structure
Pharmaceutical chemistry
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro; Title Page; Copyright Page; Contents; Chapter 1 Introduction; 1.1 The Original Definition of Privileged Structures; 1.2 The Role of Privileged Structures in the Drug Discovery Process; 1.3 The Loose Definitions of â#x80;#x9C;Privileged Structuresâ#x80;#x9D;; 1.4 Synthesis and Biological Activities of Carbocyclic and Heterocyclic Privileged Structures; 1.4.1 Synthesis and Biological Activities of Three- and Four-Membered Ring Privileged Structures; 1.4.2 Synthesis and Biological Activities of Five-Membered Ring Privileged Structures
  • 1.4.3 Synthesis and Biological Activities of Six-Membered Ring Privileged Structures1.4.4 Synthesis and Biological Activities of Bicyclic 5/5 and 6/5 Ring Privileged Structures; 1.4.5 Synthesis and Biological Activities of Bicyclic 6/6 and 6/7 Ring Privileged Structures; 1.4.6 Synthesis and Biological Activities of Tricyclic and Tetracyclic Ring Privileged Structures; 1.5 Combinatorial Libraries of â#x80;#x9C;Privileged Structuresâ#x80;#x9D;; 1.6 Scope of this Monograph; References; Chapter 2 Benzodiazepines; 2.1 Introduction; 2.2 Marketed BDZ Drugs; 2.2.1 1,4-Benzodiazepine Marketed Drugs
  • 2.2.2 1,5-Benzodiazepine Marketed Drugs2.2.3 Linearly Fused BDZ Marketed Drugs; 2.2.4 Angularly Fused-1,4-Benzodiazepine Marketed Drugs; 2.3 Medicinal Chemistry Case Studies; 2.3.1 Cardiovascular Applications; 2.3.2 Central Nervous System Applications; 2.3.3 Gastrointestinal Applications; 2.3.4 Infectious Diseases Applications; 2.3.5 Inflammation Applications; 2.3.6 Metabolic Diseases Applications; 2.3.7 Oncology Applications; 2.4 Synthesis of BDZs; 2.4.1 Condensation of o-Phenylenediamines to 1,5-Benzodiazepines; 2.4.1.1 Condensation of o-Phenylenediamines with Ketones
  • 2.4.1.2 Condensation of o-Phenylenediamines with α, β-Unsaturated Ketones2.4.1.3 Condensation of o-Phenylenediamines with Alkynes; 2.4.2 Reductive Condensation of α-Substituted Nitrobenzenes with Ketones and α, β-Unsaturated Ketones; 2.4.3 Intramolecular Cyclizations to 1,4-Benzodiazepines; 2.4.3.1 Intramolecular Cyclizationsâ#x80;#x94;Path A; 2.4.3.2 Intramolecular Cyclizationsâ#x80;#x94;Path B; 2.4.3.3 Intramolecular Cyclizationsâ#x80;#x94;Path C; 2.4.3.4 Intramolecular Cyclizationsâ#x80;#x94;Path D; 2.4.3.5 Intramolecular Cyclizationsâ#x80;#x94;Path E; 2.4.3.6 Intramolecular Cyclizationsâ#x80;#x94;Path F
  • 2.4.3.7 Intramolecular Cyclizationsâ#x80;#x94;Path G2.4.3.8 Intramolecular Cyclizationsâ#x80;#x94;Path H; 2.4.4 Ugi Multicomponent Synthesis; 2.4.5 Elaboration of 1,4-Benzodiazepines; 2.4.6 Pyrrolo[2,1-c]benzodiazepines; 2.4.7 Fused BDZ Ring Systems; 2.4.8 Solid-Phase Synthesis of BDZs; References; Chapter 3 1,4-Dihydropyridines; 3.1 Introduction; 3.2 Marketed 1,4-Dihyropyridine Drugs; 3.3 Medicinal Chemistry Case Studies; 3.3.1 Cardiovascular Applications; 3.3.2 Central Nervous System Applications; 3.3.3 Infectious Diseases Applications; 3.3.4 Inflammation Applications
  • 3.3.5 Menâ#x80;#x99;s and Womenâ#x80;#x99;s Health Issues Applications

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