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Boron-based compounds : potential and emerging applications in medicine /
Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics' Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for m...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, NJ, USA :
John Wiley & Sons, Ltd,
2018.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- List of Contributors vii Preface xi Part 1 Design of New Boron-based Drugs 1 1.1 Carboranes as Hydrophobic Pharmacophores: Applications for Design of Nuclear Receptor Ligands 3; Yasuyuki Endo 1.2 Boron Cluster Modifications with Antiviral, Anticancer, and Modulation of Purinergic Receptors' Activities Based on Nucleoside Structures 20; Anna Adamska-Bartłomiejczyk, Katarzyna Bednarska, Magdalena Białek-Pietras, Zofia M. Kiliańska, Adam Mieczkowski, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Zofia Sułowska, Jolanta D. Żołnierczyk, and Zbigniew J.
- Lesnikowski 1.3 Design of Carborane-Based Hypoxia-Inducible Factor Inhibitors 35; Guangzhe Li, Hyun Seung Ban, and Hiroyuki Nakamura 1.4 Half- and Mixed-Sandwich Transition Metal Dicarbollides and nido-Carboranes( -1) for Medicinal Applications 60; Benedikt Schwarze, Marta Gozzi, and Evamarie Hey-Hawkins 1.5 Ionic Boron Clusters as Superchaotropic Anions: Implications for Drug Design 109; Khaleel I. Assaf, Joanna Wilinska, and Detlef Gabel 1.6 Quantum Mechanical and Molecular Mechanical Calculations on Substituted Boron Clusters and Their Interactions with Proteins 126; Jindřich Fanfrlík, Adam Pecina, Jan Řezáč, Pavel Hobza, and Martin Lepšík Part 2 Boron Compounds in Drug Delivery and Imaging 139 2.1 Closomers: An Icosahedral Platform for Drug Delivery 141; Satish S.
- Jalisatgi 2.2 Cobaltabisdicarbollide-based Synthetic Vesicles: From Biological Interaction to in vivo Imaging 159; Clara Viñas, Francesc Teixidor, and Adrian J. Harwood 2.3 Boronic Acid-Based Sensor for Determination of Sugars 174; Igor B. Sivaev and Vladimir I. Bregadze 2.4 Boron Compounds in Molecular Imaging 205; Bhaskar C. Das, Devi Prasan Ojha, Sasmita Das, and Todd Evans 2.5 Radiolabeling Strategies for Boron Clusters: Toward Fast Development and Efficient Assessment of BNCT Drug Candidates 232; Kiran B.
- Gona, Vanessa Gómez-Vallejo, Irina Manea, Jonas Malmquist, Jacek Koziorowski, and Jordi Llop Part 3 Boron Compounds for Boron Neutron Capture Therapy 269 3.1 Twenty Years of Research on 3-Carboranyl Thymidine Analogs (3CTAs): A Critical Perspective 271; Werner Tjarks 3.2 Recent Advances in Boron Delivery Agents for Boron Neutron Capture Therapy (BNCT) 298; Sunting Xuan and Maria da Graça H. Vicente 3.3 Carborane Derivatives of Porphyrins and Chlorins for Photodynamic and Boron Neutron Capture Therapies: Synthetic Strategies 343; Valentina A. Ol'shevskaya, Andrei V. Zaitsev, and Alexander A.
- Shtil 3.4 Nanostructured Boron Compounds for Boron Neutron Capture Therapy (BNCT) in Cancer Treatment 371; Shanmin Gao, Yinghuai Zhu, and Narayan Hosmane 3.5 New Boronated Compounds for an Imaging-Guided Personalized Neutron Capture Therapy 389; Nicoletta Protti, Annamaria Deagostino, Paolo Boggio, Diego Alberti, and Simonetta Geninatti Crich 3.6 Optimizing the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) for Different Pathologies: Research in Animal Models Employing Different Boron Compounds and Administration Strategies 416; Amanda E. Schwint, Andrea Monti Hughes, Marcela A. Garabalino, Emiliano C.C. Pozzi, Elisa M. Heber, and Veronica A. Trivillin Index