Metallo-drugs : development and action of anticancer agents /

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Volume 18 centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Alessio, Enzo, Ang, Wee Han, Babak, Maria V., Berners-Price, Susan, Brabec, Victor, Casini, A., Farrell, Nicholas P., Freisinger, Eva (Editor ), Gorle, Anil K., Kasparkova, Jana, Lippard, Stephen J., Menon, Vijay, Messori, Luigi, Peterson, Erica J., Riddell, Imogen, Sadler, Peter J., Sigel, Astrid (Editor ), Sigel, Helmut (Editor ), Sigel, Roland K. O. (Editor ), Venkatesh, V.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin ; Boston : Walter de Gruyter GmbH, [2018]
Colección:Metal ions in life sciences ; v. 18.
Temas:
Organoplatinum compounds > Therapeutic use.
Antineoplastic agents.
Pharmaceutical chemistry.
Cisplatin.
Organoplatinum Compounds > therapeutic use
Antineoplastic Agents
Cisplatin
Chemistry, Pharmaceutical
Composés organoplatiniques > Emploi en thérapeutique.
Anticancéreux.
Chimie pharmaceutique.
Cisplatine.
MEDICAL > Pharmacology.
Antineoplastic agents
Organoplatinum compounds > Therapeutic use
Pharmaceutical chemistry
Acceso en línea:Texto completo
Tabla de Contenidos:
  • About the editors
  • Historical development and perspectives of the series / Astrid Sigel, Helmut Sigel, Roland K.O. Sigel
  • Preface to volume 18 / Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel
  • Contributors to volume 18.
  • 1. Cisplatin and oxaliplatin : our current understanding of their actions / Imogen A. Riddell, Stephen J. Lippard
  • 2. Polynuclear platinum complexes : structural diversity and DNA binding / Viktor Brabec, Jana Kasparkova, Vijay Menon, Nicholas P. Farrell
  • 3. Platinum(IV) prodrugs / V. Venkatesh, Peter J. Sadler
  • 4. Metalloglycomics / Nicholas P. Farrell, Anil K. Gorle, Erica J. Peterson, Susan J. Berners-Price
  • 5. The deceptively similar ruthenium(III) drug candidates KP1019 and NAMI-A have different actions : what did we learn in the past 30 years? / Enzo Alessio, Luigi Messori
  • 6. Multinuclear organometallic ruthenium-arene complexes for cancer therapy / Maria V. Babak, Wee Han Ang
  • 7. Medicinal chemistry of gold anticancer metallodrugs / Angela Casini, Raymond Wai-Yin Sun, Ingo Ott
  • 8. Coordination complexes of titanium(IV) for anticancer therapy / Edit Y. Tshuva, Maya Miller
  • 9. Health benefits of vanadium and its potential as an anticancer agent / Debbie C. Crans, Lining Yang, Allison Haase, Xiaogai Yang
  • 10. Gallium complexes as anticancer drugs / Christopher R. Chitambar
  • 11. Non-covalent metallo-drugs : using shape to target DNA and RNA junctions and other nucleic acid structures / Lucia Cardo, Michael J. Lucia
  • 12. Nucleic acid quadruplexes and metallo-drugs / Ramon Vilar
  • 13. Antitumor metallodrugs that target proteins / Matthew P. Sullivan, Hannah U. Holtkamp, Christian G. Hartinger
  • 14. Metallointercalators and metalloinsertors : structural requirements for DNA recognition and anticancer activity / Ulrich Schatzschneider
  • 15. Iron and its role in cancer defense : a double-edged sword / Frank Thévenod
  • 16. Copper complexes in cancer therapy / Delphine Denoyer, Sharnel A.S. Clatworthy, Michael A. Cater
  • 17. Targeting zinc(II) signalling to prevent cancer / Silvia Ziliotto, Olivia Ogle,Kathryn M. Taylor
  • Subject index.

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