Metallo-drugs : development and action of anticancer agents /

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Volume 18 centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Alessio, Enzo, Ang, Wee Han, Babak, Maria V., Berners-Price, Susan, Brabec, Victor, Casini, A., Farrell, Nicholas P., Freisinger, Eva (Editor ), Gorle, Anil K., Kasparkova, Jana, Lippard, Stephen J., Menon, Vijay, Messori, Luigi, Peterson, Erica J., Riddell, Imogen, Sadler, Peter J., Sigel, Astrid (Editor ), Sigel, Helmut (Editor ), Sigel, Roland K. O. (Editor ), Venkatesh, V.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin ; Boston : Walter de Gruyter GmbH, [2018]
Colección:Metal ions in life sciences ; v. 18.
Temas:
Organoplatinum compounds > Therapeutic use.
Antineoplastic agents.
Pharmaceutical chemistry.
Cisplatin.
Organoplatinum Compounds > therapeutic use
Antineoplastic Agents
Cisplatin
Chemistry, Pharmaceutical
Composés organoplatiniques > Emploi en thérapeutique.
Anticancéreux.
Chimie pharmaceutique.
Cisplatine.
MEDICAL > Pharmacology.
Antineoplastic agents
Organoplatinum compounds > Therapeutic use
Pharmaceutical chemistry
Acceso en línea:Texto completo
Descripción
Sumario:Volume 18 centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
Descripción Física:1 online resource (588 pages)
Bibliografía:Includes bibliographical references and index.
ISBN:9783110470734
311047073X
9783110470741
3110470748
3110469901
9783110469905
ISSN:1559-0836 ;

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