Heart Failure in the Child and Young Adult : From Bench to Bedside.

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Jefferies, John L.
Otros Autores: Chang, Anthony C., Rossano, Joseph W., Shaddy, Robert E., Towbin, Jeffrey A.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Saint Louis : Elsevier Science, 2017.
Temas:
Pediatric cardiology.
Cardiologie pédiatrique.
Pediatric cardiology
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Heart Failure in the Child and Young Adult; Heart Failure in the Childand Young Adult: From Bench to Bedside; Copyright; Jefferiesâ#x80;#x94;Heart Failure Dedications; Contents; List of Contributors; Preface; Foreword; REFERENCES; 1
  • Basic Science of Heart Failure; 1
  • Molecular and Cellular Mechanisms in Heart Failure; INTRODUCTION; GENETICS OF CARDIAC DYSFUNCTION AND HEART FAILURE; Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy; Left Ventricular Noncompaction; Arrhythmogenic Right Ventricular Cardiomyopathy; Restrictive Cardiomyopathy; MOLECULAR MECHANISMS OF HEART FAILURE.
  • Ventricular RemodelingCompensatory Mechanisms of Heart Failure; Inflammatory Signaling and Fibrosis; Inflammation and Oxidative Stress in Heart Failure; Mitochondrial Dysfunction; MicroRNAs; MYOCARDIAL REGENERATIVE STRATEGIES; CONCLUSION; REFERENCES; 2
  • Cardiovascular Receptors and Signaling in Heart Failure; HISTORY OF ADRENERGIC SIGNALING AND THE HEART; TRANSLATION OF BASIC RESEARCH INTO CLINICAL PRACTICE; ADVANCES IN OUR UNDERSTANDING OF Î#x92;-ADRENERGIC SIGNALING: FROM LINEARITY TO CROSS TALK; Î#x92;1 VERSUS Î#x92;2 SIGNALING: CLINICAL IMPLICATIONS.
  • BIASED SIGNALING VIA Î#x92;-ARRESTIN: CLINICAL IMPLICATIONSPHARMACOGENOMICS OF Î#x92;-RECEPTORS/Î#x92;-BLOCKERS; IMPLICATIONS FOR TREATING CHILDREN WITH HEART FAILURE; REFERENCES; 3
  • Inflammatory Mediators in Heart Failure; INTRODUCTION; INFLAMMATION IN ADULT HEART FAILURE; Prognosis and Biomarkers; Tumor Necrosis Factor (TNFSF2) and IL-6; Soluble ST2; Galectin-3 and Pentraxin-3; Mechanisms of Immune Activation; Myocardial Inflammation; Systemic Inflammation; Contribution of Inflammation to the Syndrome of Heart Failure; Effects on the Myocardium; Effects on the Vasculature.
  • Effects on Peripheral TissuesCLINICAL TRIALS OF IMMUNOMODULATION; IL-1 Signaling Inhibition; Tumor Necrosis Factor Blockade; DIFFERENCES BETWEEN THE PEDIATRIC AND ADULT HEART AND IMMUNE SYSTEM; Macrophages; Macrophage Diversity; Functions of Embryonic and Adult Macrophages in the Heart and Periphery; Macrophage Heterogeneity in the Failing Heart; Macrophage Heterogeneity in Peripheral Tissues; IMPLICATIONS FOR PEDIATRIC HEART FAILURE; REFERENCES; 4
  • Mechanisms of Cardiac Hypertrophy; INTRODUCTION; Definition and Significance of Myocardial Hypertrophy.
  • Cellular Mechanisms of Cardiac HypertrophyMolecular Mechanisms of Cardiac Hypertrophy; THE INFANT OF A DIABETIC MOTHER; Ventricular Hypertrophy; Mechanisms of Hypertrophy; Resolution of Hypertrophy; PULMONARY ARTERY BANDING; Human Studies; Adult Animal Models; Juvenile Animal Models; ATHLETEâ#x80;#x99;S HEART; Mechanisms of Hypertrophy; Factors Affecting Hypertrophy; Resolution of Hypertrophy; CONCLUSION; REFERENCES; FURTHER READING; 5
  • Hemodynamic Adaptive Mechanisms in Heart Failure; INTRODUCTION; CARDIAC FUNCTION; Stroke Volume; Preload; Afterload; Contractility; Cardiac Output/Cardiac Index.

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