Peptide Applications in Biomedicine, Biotechnology and Bioengineering.

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Koutsopoulos, Sotirios
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge : Elsevier Science, 2017.
Temas:
Peptides-Laboratory manuals.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Â#x93;Peptide Applications in Biomedicine, Biotechnology and Bioengineering
  • Copyright Page
  • Contents
  • List of contributors
  • 1 Peptide synthesis: Methods, trends, and challenges
  • 1.1 Introduction
  • 1.2 Solid phase peptide synthesis
  • 1.3 Solid supports (resins and linkers)
  • 1.3.1 Resins
  • 1.3.2 Linkers for Fmoc-based SPPS
  • 1.4 Protecting groups
  • 1.4.1 Nα amino protecting groups
  • 1.4.2 Side-chain protecting groups
  • 1.5 Coupling reagents
  • 1.6 Deprotection: Cleavage solutions
  • 1.7 Microwave-assisted solid-phase peptide synthesis1.8 Green peptide synthesis
  • 1.9 Future challenges: Conclusions
  • References
  • 2 Synthetic approaches of naturally and rationally designed peptides and peptidomimetics
  • 2.1 Natural and rationally designed peptides
  • 2.1.1 Cyclic peptides
  • 2.1.2 Disulfide-rich peptides
  • 2.1.2.1 Conotoxins
  • 2.1.2.2 Cyclotides
  • 2.1.3 Cyclodepsipeptides
  • 2.1.3.1 â#x80;#x9C;Head-to-tailâ#x80;#x9D; cyclodepsipeptides
  • 2.1.3.2 â#x80;#x9C;Head-to-side-chainâ#x80;#x9D; cyclodepsipeptides
  • 2.1.4 Lantibiotics
  • 2.1.5 Stapled peptides
  • 2.2 Peptidomimetics2.2.1 Peptoids and Peptoid derivatives
  • 2.2.2 AA-peptides
  • 2.2.3 Azapeptides
  • 2.2.4 Urea-based peptidomimetics
  • 2.2.5 Nonpeptide-based peptidomimetics
  • Acknowledgments
  • References
  • 3 Applications of de novo designed peptides
  • 3.1 Introduction
  • 3.2 Peptide building blocks
  • 3.2.1 α-Helices, helical bundles, and coiled coils
  • 3.2.1.1 α-Helices
  • 3.2.1.2 Coiled coils
  • 3.2.1.3 Helical bundles
  • 3.2.2 β-Strands and sheets
  • 3.2.2.1 β-Strands
  • 3.2.2.2 β-Sheets
  • 3.2.3 Collagens
  • 3.3 De novo designed peptide structures and their applications3.3.1 Tissue engineering and regeneration
  • 3.3.1.1 Scaffolds from self-assembled β-structured components
  • 3.3.1.2 SAFs (self-assembling fibers) from α-helical building blocks
  • 3.3.1.3 Tissue engineering and regeneration with collagen-mimetic peptides
  • 3.3.1.4 Short peptide motifs as molecular signals
  • 3.3.2 Drug encapsulation, release, and delivery
  • 3.3.2.1 Drug encapsulation and release from hydrogels
  • 3.3.2.2 Discrete structures for encapsulation, release, and delivery
  • 3.3.2.3 Translocating and permeating peptides for drug delivery3.3.3 Antigen display and vaccine development
  • 3.3.4 Membrane protein stabilization
  • 3.3.4.1 α-Helical amphipathic peptides
  • 3.3.4.2 Short, self-assembling peptides
  • 3.3.5 Imaging contrast agents
  • 3.3.5.1 Translocating and targeting peptide conjugates
  • 3.3.5.2 De novo designed chelating peptides
  • 3.3.6 3D printingâ#x80;#x94;peptide bioinks
  • 3.3.7 Nanoparticle and nanowire synthesis
  • 3.3.7.1 Peptide-directed nanoparticle synthesis
  • 3.3.7.2 Nanowire synthesis
  • 3.4 Conclusions and outlook

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