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Cerebrospinal fluid in neurologic disorders /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2017.
|
| Colección: | Handbook of clinical neurology ;
volume 146. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover
- Cerebrospinal Fluid in Neurologic Disorders
- Copyright
- Available titles
- Foreword
- Preface
- Contributors
- Contents
- Section I: General aspects
- Chapter 1: The use of cerebrospinal fluid in biomarker studies
- Introduction
- Definition of biomarkers and type of biomarkers
- Physiology of CSF
- Biomarker subtypes
- Proteins
- Metabolites
- Cell-free DNA
- Messenger RNA/micro RNA
- Exosomes
- Sample collection and biobanking: preanalytic variation
- Patient-related factors
- Age and sex
- Genetic backgroundCircadian rhythm
- Coffee, chocolate, smoking, and alcohol consumption
- Preanalytic procedures
- Lumbar puncture
- Risk factors and recommendations in performing an LP
- Type of tube
- Evaporation
- Centrifugation speed and temperature
- Quality assessment of collection procedures
- Analytic aspects in CSF biomarker studies: assay development and validation
- Technical analysis: optimizing immunoassay validation and development of novel biomarkers
- Quality assessment of analytic procedures
- Matrix reference material
- Clinical study design in CSF biomarker studiesDiscussion: how to increase the number of novel biomarkers?
- Concluding remarks
- References
- Chapter 2: The cerebrospinal fluid and barriers
- anatomic and physiologic considerations
- Introduction
- Physiology of CSF: what is CSF good for, where does it come from, how is it circulating, where does it go?
- Biologic function
- Sites of production
- Circulation
- Absorption
- Transfer mechanisms
- Barriers of the CNS compartment: what are the differences between BBB and BCB?
- The blood-brain barrier
- The blood-CSF barrierAnatomy of CSF spaces: which brain areas are reflected by CSF analysis?
- CSF constituents: which factors influence their concentration and what is their implication for CSF analysis?
- Circadian changes
- Site of sampling (lumbar vs. ventricular CSF)
- Volume of CSF sampled
- Physical activity and head movement
- Clearance via specific transporters
- Surgical intervention
- Concluding remarks
- References
- Chapter 3: More than a drainage fluid: the role of CSF in signaling in the brain and other effects on brain tissue
- The concept of volume transmissionThe functional influence of CSF on brain cells
- Adult neurogenesis
- CSF-contacting neurons
- The functional contribution of CSF in pathologic CNS conditions
- Traumatic brain injury (TBI)
- Anti-NMDAR encephalopathy
- Brain aging and dementia
- Summary
- Abbreviations
- References
- Chapter 4: Dosing, collection, and quality control issues in cerebrospinal fluid research using animal models
- Introduction
- CSF and brain interstitial fluid