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|a Cerebrospinal fluid in neurologic disorders /
|c volume editors, Florian Deisenhammer, Charlotte E. Teunissen, and Hayrettin Tumani.
|
| 260 |
|
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|a Amsterdam :
|b Elsevier,
|c 2017.
|
| 300 |
|
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|a 1 online resource
|
| 336 |
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|a text
|b txt
|2 rdacontent
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| 490 |
1 |
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|a Handbook of clinical neurology ;
|v volume 146
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| 588 |
0 |
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|a Online resource; title from PDF title page (EBSCO, viewed November 1, 2017)
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| 504 |
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|a Includes bibliographical references and index.
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| 505 |
0 |
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|a Front Cover -- Cerebrospinal Fluid in Neurologic Disorders -- Copyright -- Available titles -- Foreword -- Preface -- Contributors -- Contents -- Section I: General aspects -- Chapter 1: The use of cerebrospinal fluid in biomarker studies -- Introduction -- Definition of biomarkers and type of biomarkers -- Physiology of CSF -- Biomarker subtypes -- Proteins -- Metabolites -- Cell-free DNA -- Messenger RNA/micro RNA -- Exosomes -- Sample collection and biobanking: preanalytic variation -- Patient-related factors -- Age and sex
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| 505 |
8 |
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|a Genetic backgroundCircadian rhythm -- Coffee, chocolate, smoking, and alcohol consumption -- Preanalytic procedures -- Lumbar puncture -- Risk factors and recommendations in performing an LP -- Type of tube -- Evaporation -- Centrifugation speed and temperature -- Quality assessment of collection procedures -- Analytic aspects in CSF biomarker studies: assay development and validation -- Technical analysis: optimizing immunoassay validation and development of novel biomarkers -- Quality assessment of analytic procedures -- Matrix reference material
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| 505 |
8 |
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|a Clinical study design in CSF biomarker studiesDiscussion: how to increase the number of novel biomarkers? -- Concluding remarks -- References -- Chapter 2: The cerebrospinal fluid and barriers -- anatomic and physiologic considerations -- Introduction -- Physiology of CSF: what is CSF good for, where does it come from, how is it circulating, where does it go? -- Biologic function -- Sites of production -- Circulation -- Absorption -- Transfer mechanisms -- Barriers of the CNS compartment: what are the differences between BBB and BCB? -- The blood-brain barrier
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| 505 |
8 |
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|a The blood-CSF barrierAnatomy of CSF spaces: which brain areas are reflected by CSF analysis? -- CSF constituents: which factors influence their concentration and what is their implication for CSF analysis? -- Circadian changes -- Site of sampling (lumbar vs. ventricular CSF) -- Volume of CSF sampled -- Physical activity and head movement -- Clearance via specific transporters -- Surgical intervention -- Concluding remarks -- References -- Chapter 3: More than a drainage fluid: the role of CSF in signaling in the brain and other effects on brain tissue
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| 505 |
8 |
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|a The concept of volume transmissionThe functional influence of CSF on brain cells -- Adult neurogenesis -- CSF-contacting neurons -- The functional contribution of CSF in pathologic CNS conditions -- Traumatic brain injury (TBI) -- Anti-NMDAR encephalopathy -- Brain aging and dementia -- Summary -- Abbreviations -- References -- Chapter 4: Dosing, collection, and quality control issues in cerebrospinal fluid research using animal models -- Introduction -- CSF and brain interstitial fluid
|
| 590 |
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|a eBooks on EBSCOhost
|b EBSCO eBook Subscription Academic Collection - Worldwide
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| 590 |
|
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 650 |
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0 |
|a Cerebrospinal fluid.
|
| 650 |
|
0 |
|a Nervous system
|x Diseases.
|
| 650 |
1 |
2 |
|a Cerebrospinal Fluid
|
| 650 |
2 |
2 |
|a Nervous System Diseases
|
| 650 |
|
6 |
|a Liquide céphalorachidien.
|
| 650 |
|
6 |
|a Système nerveux
|x Maladies.
|
| 650 |
|
7 |
|a MEDICAL
|x Physiology.
|2 bisacsh
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| 650 |
|
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|a SCIENCE
|x Life Sciences
|x Human Anatomy & Physiology.
|2 bisacsh
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|x Diseases
|2 fast
|
| 650 |
|
7 |
|a Cerebrospinal fluid
|2 fast
|
| 655 |
|
4 |
|a Internet Resources.
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1 |
|
|a Deisenhammer, Florian.
|
| 700 |
1 |
|
|a Teunissen, Charlotte E.
|
| 700 |
1 |
|
|a Tumani, Hayrettin.
|
| 758 |
|
|
|i has work:
|a Cerebrospinal fluid in neurologic disorders (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCFB3tw9FPb9j7GpBfyrxwC
|4 https://id.oclc.org/worldcat/ontology/hasWork
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|t Cerebrospinal fluid in neurologic disorders.
|d Amsterdam : Elsevier, 2017
|z 9780128042793
|z 0128042796
|w (OCoLC)986237295
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|v volume 146.
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